DNA-encoded libraries have numerous advantages over traditional screening methods, including easy identification of compounds and the large quantity of compounds that can be screened simultaneously.
This book provides a comprehensive guide to the implementation of DNA-encoded library technology (DELT) in drug discovery for screening and hit validation, illustrated with successful case studies.
A valuable resource for researchers in drug discovery, this book is complete with successful case studies to illustrate the best practice in implementation and operation of DELT.
€199.99
Inhoudsopgave
- Overview of Affinity-based DEL Selections with Select Target Types and Achievements
- Machine Learning with DEL Selection Data and for DEL design
- One bead one compound (OBOC) DELs for Biochemical Screens
- Live cell-based DEL Selections
- On-DNA Medicinal Chemistry: Focused libraries, fragment expansion, and hit optimization
- DELs with Covalent Warheads
- Application of DELs for E3 Ligase Ligand and PROTAC development
Over de auteur
Purdue University, USA
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Taal Engels ● Formaat EPUB ● Pagina’s 215 ● ISBN 9781839160554 ● Bestandsgrootte 6.6 MB ● Editor Guansai Liu & Jin Li ● Uitgeverij RSC ● Stad Cambridge ● Land GB ● Gepubliceerd 2025 ● Editie 1 ● Downloadbare 24 maanden ● Valuta EUR ● ID 9929896 ● Kopieerbeveiliging Adobe DRM
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