This book, unique in its field, is a comprehensive description of all the methodologies reported for carrying out conjugate addition reactions in a stereoselective way, using small chiral organic molecules as catalysts (organocatalysts). In the last 3-4 years, this has been a rapidly growing field in organic chemistry, and many papers have appeared reporting excellent protocols for carrying out these highly efficient transformations that compete well with other classical approaches using transition metal catalysts. A particularly attractive feature of this transformation relies upon the fact that the conjugate addition (Michael and Hetero-Michael reactions) is an extraordinarily effective means to initiate cascade processes which result in the formation of complex molecules from very small and simple starting blocks. The book, written by noted experts, covers all recent advances in this hot topic, and provides a good state-of-the-art review for organic chemists working in this field and all those who wish to start projects in this area.
Inhoudsopgave
Introduction; Enantioselective conjugate reactions via iminium activation; Enantioselective conjugate reactions via enamine activation; Enantioselective conjugate reactions via hydrogen-bonding activation; Enantioselective conjugate reactions via chiral ammonium ion formation; Organocatalytic enantioselective cascade reactions
Over de auteur
Dr Efraim Reyes graduated from the University of the Basque Country in 2001 and received his Ph D in 2006 in the Department of Organic Chemistry at the Faculty of Science at the same University. After postdoctoral studies in 2007-2008 at the Aarhus University, under the supervision of Professor Dr Karl A. Jørgensen, he joined the Research Group of Asymmetric Synthesis at the Department of Organic Chemistry II at the University of the Basque Country. Current research interests focus on the design of new methodologies in asymmetric synthesis, especially asymmetric organocatalysis, and the stereocontrolled synthesis of pharmacologically active compounds. Dr Reyes has authored more than 20 research papers (2 review articles) and 3 book chapters all dealing with asymmetric synthesis.
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