This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed. It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource.
Inhoudsopgave
1. Role of alcohol oxidative metabolism in its cardiovascular and autonomic effects.- 2. Environmental aldehyde sources and the health implications of exposure.- 3. ALDH2 and cardiovascular disease.- 4. Aldehyde dehydrogenases: From alcohol metabolism to human health and precision medicine.- 5. Aldehyde dehydrogenase 2 and heart Failure.- 6. Mitochondrial aldehyde dehydrogenase in myocardial ischemic and ischemia-reperfusion injury.- 7. East Asian variant aldehyde dehydrogenase 2 genotype (ALDH2*2*) contributes to coronary artery spasm and acute myocardial infarction.- 8. Aldehyde dehydrogenases genetic polymorphism and obesity: from genomics to behavior and health.- 9. Aldehyde dehydrogenase (ALDH) 2 in diabetic heart diseases.- 10. The role of ALDH2 in sepsis and the to-be-discovered mechanisms.- 11. ALDH2 and stroke.- 12. ALDH2 and hypertension.- 13. ALDH2 and cancer therapy.- 14. ALDH2 polymorphism and ethanol consumption: A genetic-environmental interaction in carcinogenesis.- 15.ALDH2 and aging.
Over de auteur
Prof. Jun Ren is Professor at the Department of Cardiology, Zhongshan Hospital, Fudan University, China, and Associate Dean for Research & Professor of Pharmacology, University of Wyoming College of Health Sciences, USA.
Prof. Yingmei Zhang is Professor at the Department of Cardiology, Zhongshan Hospital, Fudan University, China.
Prof. Junbo Ge is an Academician of the Chinese Academy of Sciences, and Professor at the Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institute of Panvascular Medicine, Fudan University, Shanghai, China.
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