This book will assemble the views of many of the world’s experts in the field of viruses and diabetes. It will look critically at some unanswered questions, in the field. Among these, How do viruses destroy or modify the pancreatic islet? Which viruses are involved? What is the role of virus-induced cytokines> Could vaccines prevent virus-induced diabetes? Until recent technological advances, progress in the understanding of the relationship between viruses and diabetes has been hampered. New technologies are helping shed new light on these mysteries. This will be the first comprehensive volume on this topic.
Inhoudsopgave
Preface.- Historical Background: Virus Involvement in diabetes.- Historical Background: Autoimmune Diabetes.- Genetics of Type 1 Diabetes.- Non-genetic Factors in the Pathogenesis of Type 1 daibetes.- EMC Virus in Mice.- AZ Enteroviruses in the Mouse Model of Type 1 Diabetes.- Kilham Virus in rats.- Reoviruses in Mice.- Ljungan Virus.- Virus-related Diabetes in Cattle.- Epidemiology of Viruses in Type 1 Diabetes.- Molecular Biology of Enteroviruses.- Laboratory Diagnosiws of Enterovirus Infection.- Enterovirus Immunity and the ‘Hygeine Hypothesis’.- Enteroviruses in Blood.- Coxsackieviruses and Insulitis.- Viruses in the Pancreas in Diabetes.- Other Possible Diabetogenic Viruses: Rotavirus.- Viruses, Diabetes and Autoimmunity: Studies of Subjects at Genetic Risk for Type 1 Diabetes.- Diabetes and Viruses in the Tropics.- Diabetes and Viruses in Australia and the Pacific.- Fulminant Diabetes in Japan.- Defining Causal Relationship: From Outbreak Workup to Clinical Trial.- The n POD Research Organization.- Genes, Viruses and Molecular Mimicry.- Innate and Cell-mediated Immunity to Enteroviruses.- Innate Responses to Diabetes-Producing Viruses.- Virus Infection of Human Islets In Vitro.- Virus-Induced Cytokines in Human Islets.- Antibody Enhancement of Enterovirus Infection.- Speculation on Diabetes Prevention.- Viruses as Major Environmental Factors for the Induction of Diabetes.- Sumary and Perspectives.- Index.
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