Written by two experienced college teachers from the USA, this is the only entry-level textbook on the subject currently available.
The authors begin by explaining some basics in membrane biochemistry, hormone biology, and the concept of receptor based signaling as the main form of communication between cells and of cells with the environment. They then go on to cover each receptor superfamily in detail, including their structure and evolutionary context. The text concludes with a discussion of those areas in the biosciences where receptors play a crucial role: pharmacology, developmental biology, neurobiology, and evolutionary biology.
Highly accessible, this text is perfectly suited for all courses covering receptor based signaling, regardless of whether they are part of the biology, medicine or pharmacology syllabus.
Inhoudsopgave
1 Introduction
2 The Origins of Chemical Thinking
I FUNDAMENTALS
3 Membranes and Proteins
4 Hormones as First Messengers
5 Receptor Theory
II RECEPTOR TYPES AND FUNCTION
6 Transduction I: Ion Channels and Transporters
7 Transduction II: G Protein-coupled Receptors
8 Transduction III: Receptor Kinases and Immunoglobulins
9 Transduction IV: Nuclear Receptors
III APPLICATIONS
10 Signaling Complexity
11 Cell Interactions in Development
12 Receptor Mechanisms in Disease Processes
13 Receptors and the Mind
14 Evolution of Receptors, Transmitters, and Hormones
Over de auteur
Michael Roberts is Professor of Biology at Linfield College in Mc Minnville (Oregon, USA). He has taught biology to students for 40 years, first at Yale University and since 1981 at Linfield College. His scientific focus is cardiovascular physiology and the regulation of animal body temperature.
Anne Kruchten is Associate Professor of Biology at Linfield College in Mc Minnville (Oregon, USA). A graduate of the University of Minnesota, she joined Linfield College in 2006. Her scientific focus is the regulation of cell migration.
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