This book provides a broad overview of pancreatic neuroendocrine neoplasms, focusing on the most important developments in the technologies used to diagnose, classify and treat them. After a historical and epidemiological overview, the opening chapters examine the various diagnostic approaches (radiology, nuclear medicine, endocrinology, cytology and immunohistochemistry) and discuss the WHO classification. The functioning and nonfunctioning tumor types are then fully discussed, covering epidemiology, diagnosis, morphology and prognosis of each entity. Careful consideration is given to the molecular features that have contributed in understanding the pathogenesis of such neoplasms and may have potential implications for the diagnostic and therapeutic pathways. The final chapters consider the surgical and medical approaches to therapy, providing a practical and analytical overview of the available options. The book is written by a multidisciplinary team of worldwide-recognized experts and is addressed to radiologists, nuclear medicine physicians, endocrinologists, pathologists, surgeons and oncologists.
Inhoudsopgave
Historical background and epidemiology.- Radiological diagnosis.- Nuclear medicine diagnosis.- Endocrinological approach to diagnosis.- Cytological diagnosis.- Classification.- Immunohistochemical approach to diagnosis.- Insulinoma.- Glucagonoma.- Somatostatinoma.- VIPoma.- Gastrinoma.- ACTH-producing tumor.- Serotonin-producing tumor.- GRF-, GH-, Ghrelin- and PTH-producing tumor.- Nonfunctioning pancreatic neuroendocrine neoplasms including PP-, calcitonin- and neurotensin-producing tumors.- Poorly differentiated neuroendocrine carcinoma of the pancreas.- Mixed adenoneuroendocrine carcinoma of the pancreas.- Hyperplastic and dysplastic pancreatic neuroendocrine lesions.- Molecular pathology.- Surgical therapy.- Pharmacological therapy.
Over de auteur
Stefano La Rosa. In 1998 he joined the Department of Pathology, Ospedale di Circolo, Varese, Italy and in the following years was appointed Assistant Professor of Pathology at the University of Insubria, Varese. Dr. La Rosa’s main field of interest is neuroendocrine pathology, with special reference to neuroendocrine tumors of the gut and pancreas. He is a member of the editorial boards of Frontiers in Pathology and Advances in Medicine, as well as a reviewer for many other journals. His awards include the Leonardo Mosca Award and the Cesare Biancifiori Award from the Italian Division of the International Academy of Pathology. He is member of the following scientific societies: European Society of Pathology (ESP), International Academy of Pathology (IAP), Società Italiana di Anatomia Patologica e di Citopatologia Diagnostica (SIAPEC), United States & Canadian Academy of Pathology (USCAP), Endocrine Pathology Society, European Neuroendocrine Tumor Society (ENETS), Associazione Italiana per i Tumori Neuroendocrini (ITANET) and Italian Association of Rare Tumors (IART). He is the secretary of the Endocrine Working Group of the ESP and is the head or co-author of more than 100 papers including original articles and book chapters.
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