This text illustrates bone marrow aspirate, imprint and biopsy specimens showing characteristic features of a wide variety of neoplastic and non-neoplastic conditions. While the focus is on Wright-stained smears and hematoxylin-eosin stained biopsies, other key histochemical and immunohistochemical stains are illustrated that are vital for proper diagnosis. After a brief review of the normal bone marrow, reactive changes in the marrow are illustrated, including the bone marrow response in constitutional disorders and to metabolic changes throughout the body. This is followed by specific infectious disorders in the marrow and other non-neoplastic disorders. The remainder of the Atlas illustrates the various neoplasms that involve the bone marrow, including leukemias, lymphomas and non-hematopoietic neoplasms. The hematologic neoplasms are classified using the 2016 World Health Organization (WHO) classification. This overview of bone marrow disorders illustrates a wide variety of diseases that practicing pathologists and hematologists will encounter in their routine practice.
Inhoudsopgave
Normal Bone Marrow.- Reactive Changes.- Post-Therapy Marrow Changes.- Constitutional, Metabolic and Related Disorders.- Bone Marrow Infections.- Bone Marrow Lymphoma.- Plasma Cell Neoplasms.- Immunodeficiency-Associated Lymphoproliferative Disorder.- Lymphoblastic Leukemia/Lymphoma.- Myelodysplastic Syndrome.- Acute Myeloid Leukemia.- Myeloid Proliferations of Down Syndrome.- Acute Leukemias of Ambiguous Lineage.- Histiocytic Disorders.- Myeloproliferative Neoplasms and Mastocytosis.- Myeloid and Lymphoid Neoplasms with Eosinophilia.- Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN).- Metastatic Tumors in Bone Marrow
Over de auteur
Tracey I. George, MD
Professor and Vice Chair of Clinical Affairs
Division Chief, Hematopathology
Department of Pathology
University of New Mexico Health Sciences Center
Albuquerque, NM, USA
Daniel A. Arber, MD
Professor and Chair
Department of Pathology
The University of Chicago
Chicago, IL , USA
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