Rich in detail, Hippocampal Microcircuits: A Computational Modeler’s Resource Book provides succinct and focused reviews of experimental results. It is an unparalleled resource of data and methodology that will be invaluable to anyone wishing to develop computational models of the microcircuits of the hippocampus. The editors have divided the material into two thematic areas. Covering the subject’s experimental background, leading neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Here, ensemble activity, related to behavior, on the part of morphologically identified neurons in anesthetized and freely moving animals, lead to insights into the functions of hippocampal areas. In the second section, on computational analysis, computational neuroscientists present models of hippocampal microcircuits at various levels of detail, including single-celland network levels. A full chapter is devoted to the single-neuron and network simulation environments currently used by computational neuroscientists in developing their models.
In addition to the above, the chapters also identify outstanding questions and areas in need of further clarification that will guide future research by computational neuroscientists.
Inhoudsopgave
Experimental Background.- Connectivity of the Hippocampus.- Morphology of Hippocampal Neurons.- Physiological Properties of Hippocampal Neurons.- Glutamatergic Neurotransmission in the Hippocampus.- Fast and Slow GABAergic Transmission in Hippocampal Circuits.- Synaptic Plasticity at Hippocampal Synapses.- Neuromodulation of Hippocampal Cells and Circuits.- Neuronal Activity Patterns During Hippocampal Network Oscillations In Vitro.- Neuronal Activity Patterns in Anaesthetized Animals.- Spatial and Behavioral Correlates of Hippocampal Neuronal Activity: A Primer for Computational Analysis.- Computational Analysis.- The Making of a Detailed CA1 Pyramidal Neuron Model.- CA3 Cells: Detailed and Simplified Pyramidal Cell Models.- Entorhinal Cortex Cells.- Single Neuron Models: Interneurons.- Gamma and Theta Rhythms in Biophysical Models of Hippocampal Circuits.- Associative Memory Models of Hippocampal Areas CA1 and CA3.- Microcircuit Model of the Dentate Gyrus in Epilepsy.- Multi-level Models.- Biophysics-Based Models of LTP/LTD.- A Phenomenological Calcium-Based Model of STDP.- Computer Simulation Environments.
Over de auteur
Dr. Vassilis Cutsuridis is a Research Fellow in the Department of Computing Science and Mathematics at the University of Stirling, Scotland, UK.Bruce P. Graham is a Reader in Computing Science in the Department of Computing Science and Mathematics at the University of Stirling.Stuart Cobb is a Senior Lecturer in the Neuroscience and Molecular Pharmacology Department at the University of Glasgow, Scotland, UK.Imre Vida is a Senior Lecturer in the Neuroscience and Molecular Pharmacology Department at the University of Glasgow.
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