This book describes biosynthetic methods to synthesize heterocyclic
compounds, offering a guide for the development of new drugs based
on natural products. The authors explain the role of natural
products in chemistry and their formation along with important
analytical methods and techniques for working with
heterocycles.
* Covers methods and techniques: isotopic labelling,
enzymes and mutants, and pathway identification
* Provides a thorough resource of information
specifically on heterocyclic natural products and their practical
biosynthetic relevance
* Explains the role of natural products in chemistry and
their formation
* Discusses gene cluster identification and the use of
biogenetic engineering in pharmaceutical application
About the author
Patrizia Diana is full Professor of Medicinal Chemistry
at the University of Palermo. She is currently coordinator of the
Medicinal and Biological Section of the Department of Science and
Technology: Chemical, Biological, and Pharmaceutical (STEBICEF);
and is a member of the Italian Chemical Society and International
Society of Heterocyclic Chemistry.
Girolamo Cirrincione is full Professor of Medicinal
Chemistry at the University of Palermo. He is a member of the Drug
Discovery Committee of the Pharmacology and Molecular Mechanisms
(PAMM)Group of the European Organization for Research and Treatment
of Cancer; the Italian Chemical Society, where he is currently
serving as President of the Medicinal Chemistry Division; and the
International Society of Heterocyclic Chemistry, where he served
as vice president for 2004-05
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