Replicating Vaccines

Philip R. Dormitzer & Christian W. Mandl

Philip R. Dormitzer & Christian W. Mandl
Replicating Vaccines [PDF ebook]
A New Generation

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Cover of Philip R. Dormitzer & Christian W. Mandl: Replicating Vaccines (PDF)

Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.

€213.99

Table of Content

SECTION 1: Today’s Live Attenuated Vaccines.- Live Vaccines and their Role in Modern Vaccinology.- Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster.- Classical Live Viral Vaccines.- SECTION 2: Genetically Attenuated Micro-Organisms as Vaccines.- Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus.- Live Attenuated Shigella Vaccines. Is encouraging good enough?.- New generation BCG vaccines.- SECTION 3: Manipulating Host-Pathogen Interactions to Make Vaccines.- Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines.- Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation Approaches.- An Attenuated Herpes implex Virus 1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell to Cell and Neuronal Spread.- RSV Deletion Mutant – Innate Immunity.- Live Attenuated Cholera Vaccines: Flagella and Reactogenicity.- SECTION 4: New Types of Replicating Vaccines.- Replication-defective Herpes simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors.- Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines.- Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines.- Alphavirus Particle-based Vaccine Vectors.- Recombinant, Chimeric, Live, Attenuated Vaccines against Flaviviruses and Alphaviruses.

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Language English ● Format PDF ● Pages 447 ● ISBN 9783034602778 ● File size 6.4 MB ● Age 02-99 years ● Editor Philip R. Dormitzer & Christian W. Mandl ● Publisher Springer Basel ● City Basel ● Country CH ● Published 2010 ● Downloadable 24 months ● Currency EUR ● ID 5232276 ● Copy protection Social DRM

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