This book constitutes the refereed proceedings of the 6th International Conference on Active Media Technology, AMT 2010, held in Toronto, Canada, in August 2010. The 52 revised full papers and 2 invited talks were carefully reviewed and selected for inclusion of the book. They are grouped in topcial sections on active computer systems and intelligent interfaces; adaptive Web sysetms and information foraging agents; AMT for semantic Web and Web 2.0; data mining, ontology mining and Web reasoning; e-commerce and Web services; entertainment and social applications of active media; evaluation of active media and AMT based systems; intelligent information retrieval; machine learning and human-centered robotics; multi-agent systems; multi-modal processing, detection, recognition, and expression analysis; semantic computing for active media and AMT-based systems; smart digital media; Web-based social networks; and Web mining, wisdom Web and Web intelligence.