The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health.
Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Spis treści
SECTION I: BIOMOLECULAR ASPECTS OF HSP60 .- Chapter 1.
HSP60: A Story as Long as Life on the Earth.- Chapter 2. Single-Ring Intermediates in the Catalytic Cycle of the Human Mitochondrial HSP60.- Chapter 3.
HSP60 Inhibitors and Modulators.- Chapter 4.
HSP60 as Modulators of Apoptosis.- Chapter 5.
Utilizing The Unique Architecture And Abilities of Hsp60 In Drug Development.- Chapter 6.
Role of The Post-Translational Modifications of HSP60 In Disease.-
SECTION II: HSP60 AND CANCER.- Chapter 7.
Evaluation of Heat Shock Protein 60 (HSP60) Chaperonin in Oncology.- Chapter 8.
Exosomal Hsp60: a Tumor Biomarker?.- Chapter 9.
HSP60 in Cancer Immunity: Biological Basis, Diagnostic Potential and Therapeutic Opportunities.- Chapter 10.
Hsp60 Involvement During Carcinogenesis.-
SECTION III: HSP60 AND INFLAMMATORY DISEASES AND DISORDERS.- Chapter 11.
Anti-Human Hsp60 Autoantibodies in Autoimmune and Inflammatory Rheumatic Diseases.- Chapter 12.
Hsp60 In Inflammatory Disorders.-
SECTION IV: HSP60 AND CARDIOVASCULAR DISEASES AND DISORDERS.- Chapter 13.
HSP60 In Atherosclerosis – Past, Present and Future.- Chapter 14.
Cardiac Myopathy In Conditional HSP60 Transgenic Mice.-
SECTION V: HSP60 AND NEUROLOGICAL AND NEUROSCIENCES.- Chapter 15.
Heat Shock Protein 60: An Effective Target Candidate In Neurological Diseases Treatment.- Chapter 16.
Hsp60 In Modifications of Nervous System Homeostasis and Neurodegeneration.-
SECTION VI: HSP60 AND SKELETAL MUSCLE DISEASES AND DISORDERS .- Chapter 17.
Hsp60 in Skeletal Muscle: From Molecular Anatomy To Pathophysiology.- Chapter 18.
Heat Shock Protein 60 (HSP60): Its Role in Skeletal Muscle Diseases and Novel Prospects for Therapy.- Chapter 19.
Heat Shock Protein 60 Regulation of Skeletal Tissue Integrity.-
SECTION VII: HSP60 IN HUMAN HEALTH.- Chapter 20.
Role of HSP60 In The Steroidogenesis and Reproduction.- Chapter 21.
Heat Shock Protein 60 in Skin Diseases.
O autorze
Prof. Dr. Alexzander A. A. Asea is a highly innovative and accomplished world renowned clinical and basic research scientist and visionary executive leader who has exceptional experience spearheading clinical and basic science research, training, education, and commercialization initiatives within top ranked academic biomedical institutes. Prof. Dr. Asea’s initial findings studying the effects of Hsp72 on human monocytes lead to the proposal of a novel paradigm that Hsp72, previously known to be an intracellular molecular chaperones, can be found in the extracellular milieu where it has regulatory effects on immuno-competent cells – a term now called chaperokine. Prof. Asea has authored over 255 scientific publications including peer-reviewed articles, reviews, books, book chapters, editorials, and news headliners in a wide range of biomedical-related disciplines. Prof. Asea is the series editor of the widely successful book series Heat Shock Proteins (Springer Nature Publishing) and is an editorial board member of numerous scientific peer-reviewed journals. Currently, Prof. Dr. Asea is at the University of Toledo College of Medicine and Life Sciences in Toledo, USA.
Dr. Punit Kaur is an expert in onco-proteogenomics, with extensive training and experience in quantitative mass spectrometry imaging, protein chemistry and biomarker discovery. Dr. Kaur’s main research focus is on the use of heat-induced nanotechnology in combination with radiotherapy and chemotherapy in the cancer stem cell therapy. Dr. Kaur has published more than 40 scientific articles, book chapters, and reviews, and currently serves as editorial board member for the European Journal of Cancer Prevention and the Journal of Proteomics and Bioinformatics. Dr. Kaur is an editor of 9 books in the highly successful Heat Shock Proteins book series by Springer Nature Publishers. Currently, Dr. Kaur is a Visiting Scientist Professor at the University of Texas MD Anderson Cancer Center in Houston, USA.
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