This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I – HSP and Stress Responses; Section II – Chaperone Functions of HSP; Section III – HSP in Human Diseases; Section IV – Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.
Spis treści
HSP AND STRESS RESPONSES.- Regulation of Mammalian HSP70 Expression and Stress Response.- Heat Shock Proteins and Pesticide Stress.- Heat Shock Proteins and Abiotic Stress Tolerance in Plants.- Heat Shock Proteins in Stress in Teleosts.- Life in Suspended Animation: Role of Chaperone Proteins in Vertebrate and Invertebrate Stress Adaptation.- Heat Shock Proteins as Sensors for Mechanical Stress.- CHAPERONE FUNCTION OF HSP.- The 70 KDA Heat Shock Protein Hsp70 as Part of a Protein Disaggregase System.- Molecular Chaperones: Structure-Function Relationship and Their Role in Protein Folding.- ER Stress, Human Health and Role of Ca2+-Binding Chaperones.- Hsp70: A Multi-tasking Chaperone at the Crossroad of Cellular Proteostasis.- HSP IN HUMAN DISEASE.- Heat Shock Protein Response to Overuse Injuries.- Heat Shock Protein 90: Truly Moonlighting!.- Geroscience From Cell-body Dynamics and Proteostasis Cooperation Supported by αB-crystallin and Human will ~ A Proposal of “Body-Mind Integrative Science”.- Heat Shock Protein 70 (Hsp70) in the Regulation of Platelet Function.- Heat Shock Protein Responses In Septic Patients.- Heat Shock Protein 70 (HSP70) Family in Dengue Virus Infection.- Roles and Regulation of the Heat Shock Proteins of the Major Human Pathogen Helicobacter pylori.- Heat Shock Protein Expression in Various Tissues in Thermal Stress.
O autorze
Dr. Punit Kaur has extensive training and experience in proteomics and mass spectrometry at the Agilent Technologies laboratories. In 2010, Dr. Kaur received full certification as a BD FACSAria Operator. In 2014, Dr. Kaur is currently working as the Visiting Scientist Professor to The University of Texas MD Anderson Cancer Center, Houston, TX. Dr. Kaur’s main research focus is on the use of hyperthermia in combination with radiotherapy and chemotherapy, known as the triple-modality approach in the treatment of triple-negative breast cancer (TNBC). Dr. Kaur has published more than 40 scientific articles, book chapters and reviews. Dr. Kaur currently serves as Editorial Board Member for European Cancer Prevention and the Journal of Proteomics & Bioinformatics. Recently, Dr. Kaur has been selected as an Editor for Proteomics and Biomarkers, a special issue of the Journal of Proteomics & Bioinformatics. Dr. Kaur is also an Editor for 5 books entitled “Heat Shock Protein” by Springer Nature Publishers. Dr. Kaur has also been session and co-session chair for Society of Thermal Medicine and Cell Stress Society International. Dr. Kaur has also played an important role in the Scientific and Organizing Committee member for Cell Stress Society International. Dr. Kaur has played a major role in the advisory responsibilities and mentorship of 15 Undergraduate Students, 55 International Exchange Undergraduate Students, 2 Graduate Students, 4 Postdoctoral Scholars and 2 Medical Residents. Dr. Kaur has been involved in didactic teaching and laboratory courses and Grants Writing, Research Methodology and Problem-Based Learning Techniques.
Professor Dr. Alexzander A. A. Asea is a highly innovative and accomplished world-renowned clinical and basic research scientist and visionary executive leader who have exceptional experience spearheading strategic planning, clinical and basic science research, training, education and commercialization initiatives within top-ranked hospitals and academic biomedical institutes. Prof. Asea’s initial findings studying the effects of Hsp72 on human monocytes lead to the proposal of a novel paradigm; that Hsp72 previously known to be an intracellular molecular chaperone, can be found in the extracellular milieu where it has regulatory effects on immunocompetent cells. Prof. Asea has authored over 255 scientific publications including peer-reviewed articles, reviews, books, book chapters, editorials and news headliners in a wide range of biomedical related disciplines. He has also successfully obtained grant funding from the federal government, industry, philanthropic organizations, local business and community groups. Prof. Asea is the Series Editor of the widely successful book series Heat Shock Proteins (Springer Nature Publications) and is on the Editorial Board Member of 13 scientific peer reviewed other journals. Currently, Prof. Asea is at The University Of Texas MD Anderson Cancer Center, Houston, USA.
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