This book illustrates the broad field of enantioselective catalysis by highlighting a few topics, out of myriads, with the double aim to typify selected synthetic achievements and future challenges. Eleven research groups have highlighted topics of interest in either organo- or organometallic catalysis, related to their own expertise. For mature fields, these short chapters, far from being exhaustive, show updated overviews including major recent advances and disclose a few prospects. Other chapters focus on upcoming topics in enantioselective catalysis, i.e. on classes of reactions or families of catalysts that are expected to provide appealing synthetic tools when suitably mastered. For all these areas, recent studies demonstrate highly promising perspectives.

Contents:

• DNA-Based Asymmetric Catalysis: Past, Present and Future (Sidonie Aubert, Nicolas Duchemin, Jin-Lei Zhang, Michael Smietana and Stellios Arseniyadis)


• Chiral Secondary Phosphine Oxides as Preligands in Enantioselective Catalysis (Romain Membrat, Didier Nuel, Laurent Giordano and Alexandre Martinez)


• Supramolecular Regulation in Enantioselective Catalysis (Matthieu Raynal and Anton Vidal-Ferran)


• Chiral Counterions in Enantioselective Organometallic Catalysis (Louis Fensterbank, Cyril Ollivier, Antoine Roblin and Marion Barbazanges)


• Enantioselective Catalysis by Nonmetal Frustrated Lewis Pairs (Armen Panossian, Julien Bortoluzzi and Frédéric R Leroux)


• Organocatalytic and Asymmetric Processes via PIII/PV Redox Cycling (Charlotte Lorton and Arnaud Voituriez)


• Recent Advances in the Use of Three-dimensional-printed Devices in Organic Synthesis Including Enantioselective Catalysis (Sergio Rossi, Alessandra Puglisi, Laura Maria Raimondi and Maurizio Benaglia)


• Catalytic Strategies for the Enantioselective Amination of C(sp3)–H Bonds (Philippe Dauban and Tanguy Saget)


• Bifunctional Homogeneous Catalysts Based on Ruthenium, Rhodium and Iridium in Asymmetric Hydrogenation (Christophe Michon and Francine Agbossou-Niedercorn)


• Organocatalytic Enantioselective Reactions Involving Cyclic N-Acyliminium Ions (Milane Saidah and Laurent Commeiras)


• Enolate Surrogates and Unusual Nucleophiles in Stereoselective Iridium-catalyzed Allylic Substitutions (Pierre Bouillac, Manuel Barday, Thierry Constantieux and Muriel Amatore)

Readership: Graduate students, researchers and professionals in Catalyst chemistry and Organic Chemistry.

Key Features:

• Updated view of selected areas with practical synthetic usefulness. Updating is especially crucial in the field of asymmetric catalysis that, after more than 50 years of active research, remains an impactful, ever-growing area with unlimited potential, in which only a few widely applicable systems have been established so far. As an interdisciplinary science, asymmetric catalysis concerns organic chemists operating in a variety of fields, from fine to medicinal and materials chemistry, that may not have specific expertise and will therefore benefit from the focused overviews presented in this book


• Highlights of new frontiers in catalyst design and catalytic methods. To date, advances in organo- and organometallic catalysis blossom worldwide, since catalysis undeniably meet key economic and environmental concerns. These advances endlessly create new challenges for chemists working in the area of asymmetric catalysis. However, new needs as well as pioneering studies toward emerging goals may go unnoticed. Aim of this book is to shed light on some of such emerging fields and to draw the attention of the scientific community to very preliminary but promising advances. This may be an unprecedented perspective in book series devoted to asymmetric catalysis


• Basic concepts in ligands and catalyst design. Since the very beginning, innovative series of chiral catalysts have emerged either from focused design based on mechanistic hypotheses, or from serendipitous disclosures and systematic screening. However, even serendipitous disclosures have been enlightened afterwards by theoretical mechanistic studies that overall provide general concepts and guidelines in asymmetric catalysis. Such rational approaches to asymmetric catalysis are typified in this book, that will thus provide useful examples for student training and newcomers in the field