m RNA Therapeutics: Foundations, Innovations and Clinical Applications aims to provide a comprehensive text that covers all aspects of m RNA therapeutics, from the foundational science that underpins this disruptive new drug class, through the scientific and technological breakthroughs crucial for therapeutic success, to the current clinical applications and the innovative advances driving future directions. The book begins with foundational knowledge covering m RNA biology, the immune system, and vaccines. The second section addresses the major challenges associated with m RNA as a therapeutic modality, and the molecular engineering innovations and delivery technologies that have allowed these hurdles to be largely overcome. The third section describes the current and future clinical applications of m RNA therapeutics that are transforming, or are poised to transform, medicine and health. This includes the use of m RNA vaccines for COVID-19 and other infectious diseases, as well as m RNA’s role in revolutionizing cancer immunotherapy, covering immunostimulants, cancer vaccines including personalized neoantigen vaccines, and CAR T cell technologies. Additional chapters describe the use of m RNA therapeutics for protein replacement therapy and gene-editing, as well as newer m RNA constructs, including self-amplifying m RNA. The final section addresses the safety and regulatory considerations of m RNA therapeutics, along with broader cultural issues including vaccine hesitancy, global vaccine inequality, and pandemic preparedness. Currently, m RNA texts either provide personal accounts from key players involved in COVID-19 vaccine development, with limited scientific depth, or focus on highly specialized, more esoteric applications of m RNA in advanced molecular biology. This book aims to bridge this gap by providing a scientifically rigorous and wide-ranging exploration of m RNA’s role in therapeutics. This pioneering textbook serves as a vital addition to the academic canon, providing an essential tool for the current and next generation of students, scientists, researchers and professionals in a wide variety of related disciplines including molecular biology, biomedical engineering, pharmaceutical science, oncology, and the health sciences. – Focuses on the science of m RNA, covering the development, modus operandi, platform manufacturing technology, safety, and efficacy of this treatment modality- Provides the m RNA technology fit with the wider context of vaccinology, virology, oncology, biotechnology, as well as manufacturing and regulatory science- Offers an understanding of the recent paradigm shift in the way we treat disease
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