After the violence of the shootout in Palermo, Harriet regroups with the remaining members of her research team. Trinity College cancels her work and suspend her role in their research department. A researcher without research leads to more complications in her life as she seeks a way to develop her long sought after age reversal treatment.

Meanwhile, Agent Frik is still hunting Oxana as the trail of bodies grows. His life becomes complicated as the CIA set out to break the stranglehold of criminal gangs in Mexico. A friend proves to be undependable and Frik is challenged professionally, while his wife makes a mistake with serious implications.

Oxana continues to avoid capture, while ensnaring others in her criminal web. With millions in her account, she heads back to Moscow to consolidate her position as gang leader. Cristiano and Frik combine forces for one final effort to obtain justice for Ricardo, the innocent waiter killed in Seville.