The purpose of this edited book is to present and showcase the basic fundamentals, applications, and integration of both Io T and Blockchain. The trend of applying Blockchain to Io T is rapidly growing because it helps to overcome various challenges faced by Io T, from smart manufacturing to unmanned aerial vehicles. Thise book aims to showcase the basics of both Io T and Blockchain as well as the integration and challenges for existing practitioners. Thise book initiates conversations among technologists, engineers, scientists, and clinicians to synergize their efforts in producing low-cost, high-performance, highly efficient, deployable Io T systems. Thise book is theory-based and is useful for engineers from various disciplines, including industrial engineering, computer science, electronics, telecommunications, electrical, agricultural, and cybersecurity, along with researchers, professionals, and students.