Cost-effective strategies for designing novel drug delivery
systems that target a broad range of disease conditions
In vivo imaging has become an important tool for the
development of new drug delivery systems, shedding new light on the
pharmacokinetics, biodistribution, bioavailability, local
concentration, and clearance of drug substances for the treatment
of human disease, most notably cancer. Written by a team of
international experts, this book examines the use of quantitative
imaging techniques in designing and evaluating novel drug delivery
systems and applications.
Drug Delivery Applications of Noninvasive Imaging offers
a full arsenal of tested and proven methods, practices and
guidance, enabling readers to overcome the many challenges in
creating successful new drug delivery systems. The book begins with
an introduction to molecular imaging. Next, it covers:
* In vivo imaging techniques and quantitative
analysis
* Imaging drugs and drug carriers at the site of action,
including low-molecular weight radiopharmaceuticals, peptides and
proteins, si RNA, cells, and nanoparticles
* Applications of imaging techniques in administration routes
other than intravenous injection, such as pulmonary and oral
delivery
* Translational research leading to clinical applications
* Imaging drug delivery in large animal models
* Clinical applications of imaging techniques to guide drug
development and drug delivery
Chapters are based on a thorough review of the current
literature as well as the authors’ firsthand experience working
with imaging techniques for the development of novel drug delivery
systems.
Presenting state-of-the-technology applications of imaging in
preclinical and clinical evaluation of drug delivery systems,
Drug Delivery Applications of Noninvasive Imaging offers
cost-effective strategies to pharmaceutical researchers and
students for developing drug delivery systems that accurately
target a broad range of disease conditions.
Spis treści
Preface ix
contributors xi
1 Introduction to Molecular Imaging 1
Vikas Kundra
2 PET/SPECT: Instrumentation and Imaging Techniques 12
Yuan-Chuan Tai
3 Photoacoustic Tomography and Its Applications in Drug Delivery
and Photothermal Therapy 45
Liang Song and Lihong V. Wang
4 Raman Microspectral Imaging for Label-Free Detection of
Nanoparticle-Mediated Cellular and Subcellular Drug Delivery
70
Tatyana Chernenko, Lara Milane, Christian Matthäus, Max
Diem, and Mansoor Amiji
5 A natomical and Functional MRI91
Edward F. Jackson
6 Quantitative Imaging in Drug Delivery 125
Kooresh I. Shoghi
7 PET Imaging of the Pharmacokinetics of Small Molecular-Weight
Drugs 147
Stephen M. Moerlein and Zhude Tu
8 Imaging Peptides, Proteins, and Antibody Delivery 192
Frederik L. Giesel and Clemens Kratochwil
9 In Vivo Imaging and Delivery of si RNA199
Zdravka Medarova and Anna Moore
10 Imaging Cell Therapy 223
Yajie Liang and Jeff W. M. Bulte
11 Radiolabeled Liposomes as Drug Delivery Nanotheranostics
252
William T. Phillips, Ande Bao, Keitaro Sou, Shihong Li, and Beth
Goins
12 Polymeric Micelles as Imaging Agents and Drug Delivery
Systems 268
Jun Zhao and Chun Li
13 Perfluorocarbon Nanoparticles: Translating Bench
Opportunities to the Clinic 296
G. M. Lanza, P. M. Winter, S. D. Caruthers, A. H. Schmieder, and
S. A. Wickline
14 Cancer Theranostics with Hollow Gold Nanospheres 308
Wei Lu and Chun Li
15 Imaging Pulmonary Drug Delivery 333
Stephen P. Newman
16 In Vivo Imaging for Validation of Oral Dose Performance
367
Fiona J. Mc Innes and Howard N. E. Stevens
17 Role of Large Animal Models in Translational Studies of
Imaging and Targeted Drug Delivery 389
Rajesh K. Uthamanthil and Mei Tian
18 Imaging Transcatheter Delivery to Liver Tumors 412
Adil Al-Nahhas, Meeran Naji, and Imene Zerizer
19 Direct Visualization of Therapeutic Radionuclide Distribution
Using Nuclear Medicine Imaging: I-131 in Metastatic Thyroid
Carcinoma 426
Ho Young Lee, June-Key Chung, So Won Oh, Jong Jin Lee, Keon Wook
Kang, Do Joon Park, Bo Youn Cho, and Myung Chul Lee
20 Imaging Drug Delivery to the CNS Using Translational Positron
Emission Tomography Studies 432
Chi-Ming Lee, Katarina Varnäs, and Lars Farde
Index 449
O autorze
CHUN LI, Ph D, is Professor and Ad Interim Chief,
Chemistry Section, in the Department of Cancer Systems Imaging at
the University of Texas MD Anderson Cancer Center. He is Associate
Editor of Cancer Nanotechnology and a member of the
editorial boards of American Journal of Nuclear Medicine and
Molecular Imaging and Quantitative Imaging in Medicine and
Surgery. Dr. Li has more than 120 peer-reviewed publications
and holds twenty-eight patents.
MEI TIAN, MD, is Vice President of Hangzhou Binjiang
Hospital and Professor of Diagnostic Imaging and Nuclear Medicine
at The Second Hospital, Zhejiang University School of Medicine. Dr.
Tian is also an editorial consultant for The Lancet. She is
a member of the editorial boards of Journal of Nuclear Medicine,
European Journal of Nuclear Medicine and Molecular Imaging, Nuclear
Medicine Communications, and Oncology.
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