Dalia Magana’s Building Confianza demonstrates that effective doctor-patient communication in Spanish requires that practitioners not only have knowledge of Spanish but also have transcultural knowledge of Latino/a values and language use. Using linguistic analysis to study real-time doctor-patient interactions, Magana probes the role of interpersonal language and transcultural competency in improving patient-centered health care with Spanish-speaking Latino/as, highlighting successful examples of how Latino/a cultural constructs of confianza (trust), familismo (family-orientation), personalismo (friendliness), respeto (respect), and simpatia (kindness) can be deployed in medical interactions. She proposes that transcultural interactions entail knowing patients’ cultural values and being mindful about creating an interpersonal connection with patients through small talk, humor, self-disclosure, politeness, and informal language, including language switching and culturally appropriate use of colloquialisms. By explicitly articulating discourse strategies doctors can use in communicating with Spanish-speaking patients, Building Confianza will aid both students and providers in connecting to communities of Spanish speakers in health care contexts and advancing transcultural competence.