Germ cells have a unique and critical role as the conduit for hereditary information. The issue of male germline mutagenesis and the effects on developmental defects in the next generation has become increasingly high profile in recent years. Understanding the mechanisms by which the germline is induced and maintained is one of the effective ways to treat infertility and cancer. Male-mediated Developmental Toxicity discusses these issues and provides analysis of the fundamental mechanisms of mutations covering both clinical and experimental aspects. It helps clarify the data explaining how genotoxicity involves multiple modes of action and highlights novel models and assays being used to assess germ cell genotoxicity.
With a clear focus on the various mechanisms that could impact human health, this book is for postgraduate students and researchers in reproductive and developmental toxicology as well as those with an interest in the fields of genetically inherited diseases, developmental biology and, potentially, those with a more clinical background.
Spis treści
Three Generation Study on the Male-mediated Developmental Toxicity in Mice Exposed to Bisphenol A and Bisphenol A–Irradiation Combination;Male Reproductive and Developmental Toxicity Associated with Exposure to Engineered Nanoparticles;Male Infertility Mediated by Gene Mutation;Roles of Epigenetic Modifications in Male Reproductive Toxicity;Evaluation of Drug Reproductive Toxicity and the Underlying Mechanisms;An In Vitro Male Germ Cell Assay and Its Application for Detecting Phase-specificity of Genotoxins;Prostate Cancer: A Comprehensive Overview;Neurovascular Supply of the Prostate and Corpora Cavernosa Effects on Erectile Dysfunction and Urinary Incontinence After Radical Prostatectomy;Nanoplastics and Microplastics and Their Impact on Male Reproduction – Uncovering the Hidden Hazards Using the Drosophila Model;Paternal Influence on Developmental Toxicity Following Administration of Therapeutic Drugs and Direct Impact on Developmental Toxicity;The Long Shadow of Sperm DNA Damage: A Hypothesis;Oestrogen Compounds Induce Oxidative Stress in Male Reproduction
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