This book constitutes the refereed proceedings of the 15th International Conference on Web-Based Learning, ICWL 2016, held in Rome, Italy, in October 2016.The 19 revised full papers presented together with 10 short papers and 4 poster papers were carefully reviewed and selected from 110 submissions. The papers are organized in topical sections on design for learning; education and teaching; massive open online courses; mobile learning; modeling for learning; serious games; social-collaborative learning; and support for learning.