Autor: Gerd Folkers

Wsparcie
Hugo Kubinyi studied chemistry in Vienna, Austria. After his Ph.D. thesis at the Max Planck Institute of Biochemistry in Munich he continued as a Post Doc at the German Cancer Research Centre in Heidelberg. In 1966 he joined Knoll AG, later a subsidiary of BASF AG, and in 1985 he moved to BASF AG. Since 1987, until his retirement in summer 2001, he was responsible for the Molecular Modelling, Protein Crystallography and Drug Design group of BASF, since early 1998 also for Combinatorial Chemistry in the Life Sciences. He is Professor of Pharmaceutical Chemistry at the University of Heidelberg, former Chair of The QSAR and Modelling Society, and IUPAC Fellow. From his scientific work resulted five books on QSAR, 3D QSAR, and Drug Design (the German book „Wirkstoffdesign” received the 1999 Book Award of the FCI, Association of Chemical Industry) and about 90 publications. He is a member of several Scientific Advisory Boards, coeditor of the Wiley-VCH book series „Methods and Principles in Medicinal Chemistry”, and member of the Editorial Boards of several scientific journals. Gerhard Müller graduated in Organic Chemistry from the University of Frankfurt/Main (Germany) and received his Ph D in 1992 at the Technical University of Munich. After two years in the Medicinal Chemistry department of Glaxo Verona (Italy), he joined the central research facility of the Bayer AG, Leverkusen. From 1998 onwards he was project manager of a target family approach in medicinal chemistry. From 2001 to 2003 he headed the chemistry section of Organon”s Lead Discovery Unit in Oss (The Netherlands). Since summer 2003, Gerhard Müller is the chief scientific officer of the Munich-based biotech company Axxima Pharmaceuticals AG.




87 Ebooki wg Gerd Folkers

Hugo Kubinyi & Gerhard Müller: Chemogenomics in Drug Discovery
Die Chemogenomik ist eine Brückendisziplin zwischen Chemie und Biologie, die im Rahmen der Suche nach neuen Wirkstoffen Ansätze der kombinatorischen Chemie mit Proteomik und Genomik verbindet. Zwanzi …
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€178.99
Tudor I. Oprea: Chemoinformatics in Drug Discovery
Wie lässt sich die Wirkstoffentwicklung durch den zweckgerichteten Einsatz der Chemoinformatik beschleunigen und effektivieren? Ausgewiesene Fachleute – sowohl aus großen pharmazeutischen Unternehmen …
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€250.99
Han van de Waterbeemd & Hans Lennernäs: Drug Bioavailability
The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand o …
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Angielski
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€120.99
Theodor Dingermann & Dieter Steinhilber: Molecular Biology in Medicinal Chemistry
This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, sepa …
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€216.99
Paolo Carloni & Frank Alber: Quantum Medicinal Chemistry
Ohne Computer geht es nirgends mehr, auch nicht im chemisch-pharmazeutischen Labor. Mit immer genaueren und schnelleren Simulationsalgorithmen hält die Quantenchemie Einzug in die Labors der Wirkstof …
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€138.99
Oliver Zerbe: BioNMR in Drug Research
The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wüthrich. Edited by a former coworker of Wüthrich, this book presen …
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€201.99
Hans-Joachim Böhm & Gisbert Schneider: Protein-Ligand Interactions
The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein int …
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€124.99
Robert E. Babine & Sherin S. Abdel-Meguid: Protein Crystallography in Drug Discovery
The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the b …
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€138.99
C. Oliver Kappe & Alexander Stadler: Microwaves in Organic and Medicinal Chemistry
The authors of this guide are experts on the use of microwaves for drug synthesis as well as having much experience in teaching courses held under the auspices of the American Chemical Society and th …
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€160.99
Roland Seifert & Thomas Wieland: G Protein-Coupled Receptors as Drug Targets
With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important biological process that has not yet been covered in …
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€214.99
Gabriele Cruciani: Molecular Interaction Fields
This unique reference source, edited by the world’s most respected expert on molecular interaction field software, covers all relevant principles of the GRID force field and its applications in medic …
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€160.99
Willi Bannwarth & Berthold Hinzen: Combinatorial Chemistry
The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of co …
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€286.99
David J. Triggle & Murali Gopalakrishnan: Voltage-Gated Ion Channels as Drug Targets
Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understa …
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€219.99
Michael Hamacher & Katrin Marcus: Proteomics in Drug Research
From skillful handling of the wide range of technologies to successful applications in drug discovery — this handbook has all the information professional proteomics users need. Edited by experts wo …
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€207.99
Didier Rognan: Ligand Design for G Protein-coupled Receptors
G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin st …
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€162.99
Dennis A. Smith & Han van de Waterbeemd: Pharmacokinetics and Metabolism in Drug Design
In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of …
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€111.99
Wolfgang Jahnke & Daniel A. Erlanson: Fragment-based Approaches in Drug Discovery
This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented a …
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€223.99
Eric R. Francotte & Wolfgang Lindner: Chirality in Drug Research
Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of …
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€205.99
Thierry Langer & Rémy D. Hoffmann: Pharmacophores and Pharmacophore Searches
This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field and progresses from general considerations to real life scenarios in dru …
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€156.99
Jörg Hüser: High-Throughput Screening in Drug Discovery
Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct da …
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€201.99
Klaus Wanner & Georg Höfner: Mass Spectrometry in Medicinal Chemistry
This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. …
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€219.99
Hans-Dieter Höltje & Gerd Folkers: Molecular Modeling
Written by experienced experts in molecular modeling, this books describes the basics to the extent that is necessary if one wants to be able to reliably judge the results from molecular modeling cal …
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€124.99
Joachim K. Seydel & Michael Wiese: Drug-Membrane Interactions
Barriere, Reservoir, Wirkort – die Rolle von biologischen Lipidmembranen für die Wirkung von Medikamenten auf den Organismus ist vielgestaltig. Eine genaue Kenntnis der Eigenarten von Lipidmembranen …
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€115.99
Raimund Mannhold: Molecular Drug Properties
This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real dr …
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€210.99
Roy Vaz & Thomas Klabunde: Antitargets
This practice-oriented handbook surveys current knowledge on the prediction and prevention of adverse drug reactions related to off-target activity of small molecule drugs. It is unique in collating …
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€210.99
Eckhard Ottow & Hilmar Weinmann: Nuclear Receptors as Drug Targets
Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects …
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€219.99
Han van de Waterbeemd & Bernard Testa: Drug Bioavailability
The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit …
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€241.99
Gerhard F. Ecker & Peter Chiba: Transporters as Drug Carriers
This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge …
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€201.99
Roberto Todeschini & Viviana Consonni: Molecular Descriptors for Chemoinformatics
Unangefochten die Nummer eins: Dieses in seiner Form einzigartige Verzeichnis der molekularen Deskriptoren wurde für die Neuauflage aktualisiert und deutlich erweitert. Band 1 beinhaltet eine alphabe …
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€395.99
Arun K. Ghosh: Aspartic Acid Proteases as Therapeutic Targets
In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer’s perspective. The first part provides a general introduction to the family of as …
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Angielski
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€198.99
Martine J. Smit & Sergio A. Lira: Chemokine Receptors as Drug Targets
Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has no …
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€174.99
Martine J. Smit & Sergio A. Lira: Chemokine Receptors as Drug Targets
Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has no …
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€174.99
Jarkko Rautio: Prodrugs and Targeted Delivery
This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today’s drug design. …
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€165.99
Jarkko Rautio: Prodrugs and Targeted Delivery
This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today’s drug design. …
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€165.99
Christoph Sotriffer: Virtual Screening
Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structur …
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€183.99
Christoph Sotriffer: Virtual Screening
Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structur …
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€183.99
Bert Klebl & Gerhard Müller: Protein Kinases as Drug Targets
This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pione …
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€126.99
Bert Klebl & Gerhard Müller: Protein Kinases as Drug Targets
This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pione …
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€126.99
Erik De Clercq: Antiviral Drug Strategies
By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel ther …
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€174.99
Erik De Clercq: Antiviral Drug Strategies
By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel ther …
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Angielski
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€174.99
Arun K. Ghosh: Aspartic Acid Proteases as Therapeutic Targets
In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer’s perspective. The first part provides a general introduction to the family of as …
EPUB
Angielski
DRM
€198.99
Dennis A. Smith & Charlotte Allerton: Pharmacokinetics and Metabolism in Drug Design
In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the …
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€124.99
Dennis A. Smith & Charlotte Allerton: Pharmacokinetics and Metabolism in Drug Design
In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the …
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Angielski
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€124.99
Holger Gohlke: Protein-Ligand Interactions
Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understandi …
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€160.99
Holger Gohlke: Protein-Ligand Interactions
Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development. The first part provides a basic understandi …
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Angielski
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€160.99
C. Oliver Kappe & Alexander Stadler: Microwaves in Organic and Medicinal Chemistry
Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with a …
EPUB
Angielski
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€198.99
C. Oliver Kappe & Alexander Stadler: Microwaves in Organic and Medicinal Chemistry
Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed, almost doubling the amount of chemical information with a …
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Angielski
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€198.99
Alexander Dömling: Protein-Protein Interactions in Drug Discovery
Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and …
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€160.99
Alexander Dömling: Protein-Protein Interactions in Drug Discovery
Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and …
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€160.99
Nathan Brown: Bioisosteres in Medicinal Chemistry
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles …
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€144.99
Nathan Brown: Bioisosteres in Medicinal Chemistry
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles …
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€144.99
Amit S. Kalgutkar & Deepak Dalvie: Reactive Drug Metabolites
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first c …
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€153.99
Amit S. Kalgutkar & Deepak Dalvie: Reactive Drug Metabolites
Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first c …
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€153.99
Rémy D. Hoffmann & Arnaud Gohier: Data Mining in Drug Discovery
Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from co …
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€160.99
Rémy D. Hoffmann & Arnaud Gohier: Data Mining in Drug Discovery
Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from co …
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€160.99
Nathan Brown: Scaffold Hopping in Medicinal Chemistry
This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader’s own projects. The first section serves …
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€144.99
Nathan Brown: Scaffold Hopping in Medicinal Chemistry
This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader’s own projects. The first section serves …
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€144.99
Johannes Kirchmair: Drug Metabolism Prediction
The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists. The authors provide more than a systematic overview of computational tools and …
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€169.99
Johannes Kirchmair: Drug Metabolism Prediction
The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists. The authors provide more than a systematic overview of computational tools and …
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€169.99
György Keserü & David C. Swinney: Thermodynamics and Kinetics of Drug Binding
This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. …
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€142.99
György Keserü & David C. Swinney: Thermodynamics and Kinetics of Drug Binding
This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. …
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€142.99
Vinod Patel & Roy J. Vaz: Antitargets and Drug Safety
With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided …
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€151.99
Vinod Patel & Roy J. Vaz: Antitargets and Drug Safety
With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided …
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€151.99
Friedlieb Pfannkuch & Laura Suter-Dick: Predictive Toxicology
Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predict …
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€144.99
Friedlieb Pfannkuch & Laura Suter-Dick: Predictive Toxicology
Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predict …
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€144.99
Stephen Hanessian: Natural Products in Medicinal Chemistry
The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapte …
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€162.99
Stephen Hanessian: Natural Products in Medicinal Chemistry
The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapte …
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€162.99
Jörg Holenz: Lead Generation
In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generati …
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€273.99
Jörg Holenz: Lead Generation
In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generati …
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€273.99
Karen Lackey & Bruce Roth: Medicinal Chemistry Approaches to Personalized Medicine
Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first …
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€144.99
Karen Lackey & Bruce Roth: Medicinal Chemistry Approaches to Personalized Medicine
Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first …
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€144.99
José Miguel Vela & Rafael Maldonado: In vivo Models for Drug Discovery
This one-stop reference is the first to present the complete picture — covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disor …
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€153.99
José Miguel Vela & Rafael Maldonado: In vivo Models for Drug Discovery
This one-stop reference is the first to present the complete picture — covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disor …
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€153.99
Gerhard F. Ecker & Rasmus P. Clausen: Transporters as Drug Targets
As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with …
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€142.99
Gerhard F. Ecker & Rasmus P. Clausen: Transporters as Drug Targets
As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with …
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€142.99
Spiros Liras & Andrew S. Bell: Phosphodiesterases and Their Inhibitors
Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE …
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€142.99
Spiros Liras & Andrew S. Bell: Phosphodiesterases and Their Inhibitors
Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE …
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Angielski
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€142.99
Daniel A. Erlanson & Wolfgang Jahnke: Fragment-based Drug Discovery
The secret of success in drug discovery written by the pioneers in the field with unrivaled experience in fragment-based methods. In this handbook, the first-hand knowledge imparted by the world’s le …
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€151.99
Daniel A. Erlanson & Wolfgang Jahnke: Fragment-based Drug Discovery
The secret of success in drug discovery written by the pioneers in the field with unrivaled experience in fragment-based methods. In this handbook, the first-hand knowledge imparted by the world’s le …
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€151.99
Marianne I. Martic-Kehl & Pius August Schubiger: Animal Models for Human Cancer
Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized l …
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€129.99
Marianne I. Martic-Kehl & Pius August Schubiger: Animal Models for Human Cancer
Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized l …
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€129.99
Tristan Vaughan & Jane Osbourn: Protein Therapeutics
In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the developme …
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Angielski
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€273.99
Tristan Vaughan & Jane Osbourn: Protein Therapeutics
In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the developme …
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€273.99
Gerd Folkers & Hugo Kubinyi: 3D QSAR in Drug Design
Significant progress has been made in the study of three-dimensional quantitative structure-activity relationships (3D QSAR) since the first publication by Richard Cramer in 1988 and the first volume …
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€228.86
Gerd Folkers & Hugo Kubinyi: 3D QSAR in Drug Design
Significant progress has been made in the study of three-dimensional quantitative structure-activity relationships (3D QSAR) since the first publication by Richard Cramer in 1988 and the first volume …
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€228.81
Amrei Wittwer & Gerd Folkers: Schmerz
Schmerzen begleiten uns alle. Licht in das Halbwissen über Schmerz und den Umgang damit zu bringen, ist Ziel dieses Buchs. Eine Novelle als Rahmenhandlung soll die Schmerzen im Leben der Menschen ans …
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Niemiecki
€34.00
Amrei Wittwer & Gerd Folkers: Schmerz
Schmerzen begleiten uns alle. Licht in das Halbwissen über Schmerz und den Umgang damit zu bringen, ist Ziel dieses Buchs. Eine Novelle als Rahmenhandlung soll die Schmerzen im Leben der Menschen ans …
PDF
Niemiecki
€40.00