Until recently jurisprudence largely ignored neuroscientific findings. The advent of sophisticated methodologies in the neurosciences – in particular brain imaging techniques – reduced this unawareness, and findings, pointing to clear and unequivocal relations between brain structure and brain function on the one side and personality dimensions on the other, led to a growing interest of jurisprudence in brain research. The Special Issue is intended to provide an overview over the most recent findings and technological refinements in the field of crime related neuroscientific investigations. It covers genetics, functional brain imaging, mind reading, lie detection, and many other topics.