The mechanisms of the various forms of glaucoma were unknown at the outset of the twentieth century. Late in the twentieth century, two nascent areas of research were beginning to provide glimpses of what the twenty-first century held in store for the future of glaucoma: the mechanisms of glaucomatous optic neuropathy and the molecular basis of the glaucomas. In Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities, the authors review the most current knowledge available in the field and provide a basis in which researchers can effectively study the glaucomas. The intent of the book is not primarily to describe the clinical appearances of the glaucomas nor how to manage them. Rather, it is to provide basic scientists, who are working in the field of glaucoma, with a current understanding of the clinical aspects of glaucoma, and to provide clinician scientists with the basic knowledge, as they attempt to translate it into rational treatments for glaucoma. In this important new book leaders in the various fields of glaucoma review our current understanding of glaucoma from epidemiology and genetics through molecular, cellular and tissue responses to the mechanisms of the glaucomas and the mechanisms by which we manage them. Mechanisms of the Glaucomas: Disease Processes and Therapeutic Modalities will be of great value as its contents will aid the reader in prevention of blindness from glaucoma.
Spis treści
Epidemiology of Glaucoma.- Age and Racial Variation in the Prevalence of Open-Angle Glaucoma in the USA.- Epidemiology of and Risk Factors for Primary Open-Angle Glaucoma.- The Reykjavik Eye Study on Prevalence of Glaucoma in Iceland and Identified Risk Factors.- Defined Glaucoma in Chinese Population.- The Wroclaw Epidemiological Study: Screening Possibilities of Glaucoma Detection.- Mechanisms of Intraocular Pressure Elevation in the Glaucomas.- Pretrabecular Mechanisms of Intraocular Pressure Elevation.- Glaucomatous Changes in the Trabecular Meshwork.- Trabecular Mechanisms of Intraocular Pressure Elevation.- Post-Trabecular Glaucomas with Elevated Episcleral Venous Pressure.- Angle-Closure Glaucomas Anterior (Pulling) Mechanisms.- Angle-Closure Glaucomas.- Angle-Closure Glaucomas.- Genetics of Glaucoma.- Genetics and Glaucoma Susceptibility.- Myocilin Mutations and Their Role in Open-Angle Glaucoma.- The Functional Role of Myocilin in Glaucoma.- Roles of CYP1B1, Optineurin, and WDR36 Gene Mutations in Glaucoma.- Genetic Association in the Open-Angle Glaucomas.- Apo E Polymorphisms and Severity of Open-Angle Glaucoma.- Molecular and Cellular Responses in the Eye to Glaucoma.- Changes in Aqueous Humor Dynamics with Age and Glaucoma.- Mechanosensitive Genes in the Trabecular Meshwork at Homeostasis.- Reactive Astrocytes in the Glaucomatous Optic Nerve Head.- Optic Neuropathy and Ganglion Cell Degeneration in Glaucoma.- Proteomics in Defining Pathogenic Processes Involved in Glaucomatous Neurodegeneration.- Proteomic Advances Toward Understanding Mechanisms of Glaucoma Pathology.- Molecular and Cellular Responses in the Eye to Glaucoma.- Ocular Tissue and Psychophysiological Responses.- Ocular Biomechanics in Glaucoma.- Intraocular Pressure, Perfusion Pressure, and Optic Nerve Energy Metabolism.- Optic Nerve.- Psychophysiology of Glaucoma.- Models of Glaucoma.- The Primate Model of Experimental Glaucoma.- Involvement of Inflammation in a Mouse Model of Inherited Pigmentary Glaucoma.- Use of Purified Retinal Ganglion Cells for an In Vitro Model to Study Glaucoma.- Therapeutic Modalities.- Pharmacological Therapies for Managing Glaucoma.- Redox-Based Therapies for Neuroprotection.- Neuroprotective Signaling Pathways in Glaucoma.- Role of Selective Laser Trabeculoplasty in the Management of Glaucoma.- Mechanisms and Mechanics of Incisional Surgery for Glaucoma.- Aqueous Shunts.- New Approaches to the Surgical Management of the Glaucomas.
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