Organoselenium shows incredible promise in medicine, particularly cancer therapy. This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications.
Divided into three sections, the first section describes synthetic advances in bioactive selenium compounds, revealing how organoselenium compound toxicity, redox properties and specificity can be further tuned. The second section explains the biophysics and biochemistry of organoselenium compounds, as well as selenoproteins. The final section closes with several chapters devoted to therapeutic and medicinal applications of organoselenium compounds, covering radioprotectors, anticancer agents and antioxidant behaviour.
With contributions from leading global experts, this book covers recent advances in the field and is an ideal reference for those researching organoselenium compounds.
Spis treści
An overview of organoselenium chemistry: From fundamentals to Synthesis; Looking Beyond the traditional Idea of Glutathione Peroxidase Mimics as Antioxidants; Synthesis of organoselenium compounds with potential biological activities; The Relevant Chemistry of Imidazoline-2-selone Donors with potential Biological Applications; Organoselenium cations: Structures, reactivity and applications; Organoselenium flurophores for probing ROS and heavy metals; Non-bonded selenium…heteroatom interactions in selenoenzymeglutathioneperoxidase (GPx) and mimics; Carbohydrate-derived Organoselenium Compounds: Synthesis and Application in the Structural Analysis of Biomolecules; Reaction of Selenium compounds with reactive oxygen species and the controlof oxidative stress; Reactive selenium species: Redox modulation, antioxidant, antimicrobial and anticancer activities; Ebselen and thioredoxin systems in human health, disease and therapeutic potential; History and development of selenium based radioprotectors: Distinction between inorganic vs. organic forms; Toxicology and anticancer activity of synthetic organoselenium compounds; Metabolism of selenium/selenocystine and their roles in the prevention and treatment of human cancer; Organoselenium compounds as cancer therapeutic agents; Cancer prevention by different forms of selenium
O autorze
Bhabha Atomic Research Centre, Mumbai
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