A cutting-edge review of the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.
Spis treści
Platelet Physiology.- Platelet Physiology.- Platelet Integrins and Signaling.- Platelet Adhesion.- Structure-Function of the Platelet Cytoskeleton.- Platelets and Inflammation.- Platelet Signal-Dependent Protein Synthesis.- Phosphoproteomics of Human Platelets.- Assessing Platelet Function.- Platelet Function Studies.- Platelet Function Under Flow.- Pharmacodynamics of GPIIb-IIIa Receptor Blockade.- Prostanoid Generation in Platelet Function.- Platelets and Prothrombin.- Markers of Platelet Activation and Granule Secretion.- Genomic and Proteomic Analysis of Platelets.- Clinical Applications.- Antiplatelet Agents.- Assessing Platelet Function in Clinical Trials.
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