This book covers advances in the methods of catalytic asymmetric synthesis and their applications. Coverage moves from new materials and technologies to homogeneous metal-free catalysts and homogeneous metal catalysts. The applications of several methodologies for the synthesis of biologically active molecules are discussed. Part I addresses recent advances in new materials and technologies such as supported catalysts, supports, self-supported catalysts, chiral ionic liquids, supercritical fluids, flow reactors and microwaves related to asymmetric catalysis. Part II covers advances and milestones in organocatalytic, enzymatic and metal-based mediated asymmetric synthesis, including applications for the synthesis of biologically active molecules. Written by leading international experts, this book consists of 16 chapters with 2000 References and illustrations of 560 schemes and figures.
Spis treści
PREFACE xi
FOREWORD xiii
CONTRIBUTORS xv
I NEW MATERIALS AND TECHNOLOGIES: SUPPORTED CATALYSTS,
SUPPORTS, SELFSUPPORTED CATALYSTS, CHIRAL IONIC LIQUID,
SUPERCRITICAL FLUIDS, FLOW REACTORS, AND MICROWAVES 1
1 RECYCLABLE STEREOSELECTIVE CATALYSTS 3
Carlos M. Monteiro, Alexandre F. Trindade, Pedro M. P. Gois, and
Carlos A. M. Afonso
2 RECYCLABLE ORGANOCATALYSTS IN ASYMMETRIC REACTIONS 83
Michelangelo Gruttadauria, Francesco Giacalone, and Renato
Noto
3 SYNTHESIS AND CHARACTERIZATION OF SUPPORTED CHIRAL CATALYSTS
177
Carmela Aprile, Hermenegildo Garcia, and Paolo P.
Pescarmona
4 SYNTHESIS OF CHIRAL CATALYSTS SUPPORTED ON ORGANIC POLYMERS
209
Tor Erik Kristensen and Tore Hansen
5 SELF-SUPPORTED CHIRAL CATALYSTS 257
Hongchao Guo and Kuiling Ding
6 CATALYSIS WITH CHIRALLY MODIFIED METAL SURFACES: SCOPE AND
MECHANISMS 291
Angelo Vargas, Cecilia Mondelli, and Alfons Baiker
7 CHIRAL IONIC LIQUIDS FOR ASYMMETRIC REACTIONS 323
Annie-Claude Gaumont, Yves Génisson, Frédéric
Guillen, Viacheslav Zgonnik, and Jean-Christophe Plaquevent
8 ASYMMETRIC REACTIONS IN FLOW REACTORS 345
Munawwer Rasheed, Simon C. Elmore, and Thomas Wirth
9 ASYMMETRIC CATALYTIC SYNTHESIS IN SUPERCRITICAL FLUIDS
373
Tomoko Matsuda
10 MICROWAVE-ASSISTED TRANSITION METAL-CATALYZED ASYMMETRIC
SYNTHESIS 391
Luke R. Odell and Mats Larhed
II RECENT ADVANCES IN ORGANOCATALYTIC, ENZYMATIC, AND
METAL-BASED MEDIATED ASYMMETRIC SYNTHESIS 413
11 RECENT ADVANCES ON STEREOSELECTIVE ORGANOCATALYTIC REACTIONS.
ORGANOCATALYTIC SYNTHESIS OF NATURAL PRODUCTS AND DRUGS 415
Monika Raj and Vinod K. Singh
12 RECENT ADVANCES IN BIOCATALYSIS APPLIED TO ORGANIC SYNTHESIS
491
Gonzalo De Gonzalo, Iván Lavandera, and Vicente
Gotor
13 PEPTIDES FOR ASYMMETRIC CATALYSIS 529
Matthias Freund and Svetlana B. Tsogoeva
14 SILICATE-MEDIATED STEREOSELECTIVE REACTIONS CATALYZED BY
CHIRAL LEWIS BASES 579
Maurizio Benaglia, Stefania Guizzetti, and Sergio Rossi
15 RECENT ADVANCES IN THE METAL-CATALYZED STEREOSELECTIVE
SYNTHESIS OF BIOLOGICALLY ACTIVE MOLECULES 625
Catalina Ferrer, Xavier Verdaguer, and Antoni Riera
16 STEREOSELECTIVE NITROGEN HETEROCYCLE SYNTHESIS MEDIATED BY
CHIRAL METAL CATALYSTS 671
Sherry R. Chemler
INDEX 689
O autorze
MICHELANGELO GRUTTADAURIA is Full Professor of Organic
Chemistry at the University of Palermo. His fields of interest have
previously included heterocycle synthesis, physical organic
chemistry, and stereoselective synthesis using organoselenium
chemistry. His current interests include organocatalysis and new
supported recyclable catalysts. Dr. Gruttadauria is the author of
over eighty papers and reviews.
FRANCESCO GIACALONE, Ph D, is a Researcher in the Organic
Chemistry Department at the University of Palermo. He is author or
coauthor of about forty scientific papers, including four reviews
in peer-reviewed journals, as well as fifteen book chapters and
forty congress presentations. His current research interests focus
on the preparation of recyclable materials in heterogeneous
catalysis for organic synthesis. In addition, Dr. Giacalone
coedited the book Fullerene-Polymers: Synthesis, Properties and
Applications, published by Wiley.
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