Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.
Spis treści
Genes and Polymorphisms in Cardiovascular Disease.- Angiotensin II Receptor Polymorphisms and Hypertension.- Angiotensinogen Gene Polymorphisms and Hypertension.- Substitution Mapping.- Local Production of Angiotensinogen.- Cardiovascular Pharmacogenomics.- Genetic Polymorphisms and Response to HMG-Co A Reductase Inhibitors.- Monogenic Causes of Heart Failure.- Gene Transfer for Combating Cardiovascular Disease.- Gene Therapy vs Pharmacotherapy.- Molecular Therapeutic Approaches for Myocardial Protection.- Gene Transfer and the Cardiovascular System.- Kallikrein Gene Transfer in Hypertension, Cardiovascular and Renal Disease, and Stroke.- Current and Future Novel Targets of Gene Therapy for Hypertension.- Application of Viral Gene Transfer in Studies of Neurogenic Hypertension.- Vigilant Vectors.- Gene Therapy for Celebral Arterial Diseases.- Regenerative Tissues for the Diseased Cardiovascular System.- Therapeutic Angiogenesis and Vasculogenesis for Tissue Regeneration.- Cell Transplantation.- Embryonic Stem Cells and the Cardiovascular System.
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