Explores bioconjugate properties and applications of
polymers, dendrimers, lipids, nanoparticles, and nanotubes
Bioconjugation has enabled breakthroughs across many areas of
industry and biomedicine. With its emphasis on synthesis,
properties and applications, this book enables readers to
understand the connection between chemistry and the biological
application of bioconjugated materials. Its detailed descriptions
of methods make it possible for researchers to fabricate and take
full advantage of bioconjugates for a broad range of applications.
Moreover, the book sets the foundation for the development of new
applications, including assays, imaging, biosensors, drug delivery,
and diagnostics.
Chemistry of Bioconjugates features contributions from an
international team of leading experts and pioneers in the field.
These contributions reflect the authors’ firsthand laboratory
experience as well as a thorough review of the current literature.
The book’s six sections examine:
* General methods of bioconjugation
* Polymer bioconjugates
* Organic nanoparticle-based bioconjugates
* Inorganic nanomaterial bioconjugates, including metals and
metal oxides
* Cell-based, hydrogel/microgel, and glyco-bioconjugates
* Characterization, physico-(bio)chemical properties, and
applications of bioconjugates
This comprehensive exploration of bioconjugates includes
discussions of polymers, dendrimers, lipids, nanoparticles, and
nanotubes. References at the end of each chapter serve as a gateway
to the most important original research findings and reviews in the
field.
By drawing together and analyzing all the latest chemical
methods and research findings on the physico-chemical and
biochemical properties of bioconjugates, Chemistry of
Bioconjugates sheds new light on the significance and potential
of bioconjugation. The book is recommended for organic and polymer
chemists, biochemists, biomaterial scientists, carbohydrate
chemists, biophysicists, bioengineers, and drug and gene delivery
scientists.
Spis treści
PREFACE vii
CONTRIBUTORS ix
SECTION I GENERAL METHODS OF BIOCONJUGATION
1 Covalent and Noncovalent Bioconjugation Strategies 3
Rajesh Sunasee and Ravin Narain
SECTION II POLYMER BIOCONJUGATES
2 Bioconjugates Based on Poly(Ethylene Glycol)s and
Polyglycerols 79
Rajesh A. Shenoi, Fang Gao, Muhammad Imran ul-Haq, and
Jayachandran N. Kizhakkedathu
3 Synthetic Polymer Bioconjugate Systems 104
Marya Ahmed and Ravin Narain
4 Natural Polymer Bioconjugate Systems 133
Lichao Liu, Xiuwei Pan, and Weian Zhang
5 Dendrimer Bioconjugates: Synthesis and Applications 146
Ali Nazemi and Elizabeth R. Gillies
SECTION III ORGANIC NANOPARTICLES BASED BIOCONJUGATES
6 Bioconjugation Strategies: Lipids, Liposomes, Polymersomes,
and Microbubbles 187
Anirban Sen Gupta and Horst A. von Recum
7 Organic Nanoparticle Bioconjugate: Micelles, Cross-Linked
Micelles, and Nanogels 203
Maria Vamvakaki
8 Carbon Nanotubes and Fullerene C60 Bioconjugates 239
Keshwaree Babooram and Ravin Narain
SECTION IV INORGANIC NANOMATERIALS BIOCONJUGATES (METALS,
METAL OXIDES–QUANTUM DOTS, IRON-OXIDE)
9 Gold Nanomaterials Bioconjugates 257
Qian Yang
10 Methods for Magnetic Nanoparticle Synthesis and
Functionalization 281
Mohammad H. El-Dakdouki, Kheireddine El-Boubbou, Jingguang Xia,
Herbert Kavunja, and Xuefei Huang
11 Quantum Dots Bioconjugates 315
Xiaoze Jiang, Meifang Zhu, and Ravin Narain
12 Silica Nanoparticle Bioconjugates 327
Yohei Kotsuchibashi, Mitsuhiro Ebara, and Ravin Narain
13 Polyhedral Oligomeric Silsesquioxanes (POSS) Bioconjugates
344
Weian Zhang, Zhenghe Zhang, and Lizhi Hong
SECTION V CELL-BASED, HYDROGELS/MICROGELS AND
GLYCO-BIOCONJUGATES
14 Cell-Based Bioconjugates 357
Mitsuhiro Ebara
15 Bioresponsive Hydrogels and Microgels 370
Xue Li and Michael J. Serpe
16 Conjugation Strategies Used for the Preparation of
Carbohydrate-Conjugate Vaccines 387
Rachel Hevey and Chang-Chun Ling
SECTION VI CHARACTERIZATION, PHYSICO-(BIO)CHEMICAL
PROPERTIES, AND APPLICATIONS OF BIOCONJUGATES
17 Properties and Characterization of Bioconjugates 417
Ali Faghihnejad, Jun Huang, and Hongbo Zeng
18 Physico-Chemical and Biochemical Properties of Bioconjugates
431
Marya Ahmed and Ravin Narain
19 Applications of Bioconjugates 444
Marya Ahmed and Ravin Narain
INDEX 457
O autorze
RAVIN NARAIN, Ph D, is Associate Professor in the
Department of Chemical and Materials Engineering at the University
of Alberta. He has published more than 100 articles in
peer-reviewed journals and is the editor of Engineered
Carbohydrate-Based Materials for Biomedical Applications
(Wiley). Dr. Narain’s research examines nanomedicine and
regenerative medicine, with an emphasis on developing new
biomaterials for gene delivery and tissue engineering.
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