Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more.
Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed.
Key Features:
- Describes how cancer genomics and next generation sequencing informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types
- Explains what mutations are, what tests are needed, and how to interpret the results
- Provides information on FDA-approved targeted therapies that are being used in the clinic
- Covers different sequencing platforms and technologies and how they perform in research settings
- Includes access to the fully searchable e Book
Spis treści
Contents
Contributors
Preface
Acknowledgments
1. Genetic Alterations in Cancer
Deepali Jain, Brett H. Herzog, and Leonard B. Maggi, Jr.
2. Tumor Mutational Profiling by Next-Generation Sequencing
Samantha N. Mc Nulty, Latisha Love-Gregory, and Jonathan W. Heusel
3. Bioinformatics: What a Clinician Should Know
Irena Lanc and Arpad Danos
4. Tumor Heterogeneity
Alex H. Wagner, Kilannin Krysiak, Katie M. Campbell, and Erica K. Barnell
5. Epigenetic Alterations in Cancer
Erica C. Pehrsson, Hyo Sik Jang, and Ting Wang
6. Cell-Free DNA in Cancer Diagnosis and Follow Up
Bruna Pellini Ferreira and Daniel Morgensztern
7. Optimizing Targeted Therapies Using Next-Generation Sequencing
Brett H. Herzog and Saiama N. Waqar
Index
O autorze
Ramaswamy Govindan, MD, Professor of Medicine, Co-Director of Medical Oncology, Washington University School of Medicine, St. Louis, MO
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