Over the last fifteen years, N-heterocyclic carbenes (NHCs) have mostly been used as ancillary ligands for the preparation of transition metal-based catalysts. Compared to phosphorus-containing ligands, NHCs tend to bind more strongly to metal centres, avoiding the necessity for the use of excess ligand in catalytic reactions. The corresponding complexes are often less sensitive to air and moisture, and have proven remarkably resistant to oxidation. Recent developments in catalysis applications have been facilitated by the availability of carbenes stable enough to be bottled, particularly for their use as organocatalysts. This book shows how N-heterocyclic carbenes can be useful in various fields of chemistry and not merely laboratory curiosities or simple phosphine mimics. NHCs are best known for their contribution to ruthenium and palladium-catalysed reactions but the scope of this book is much broader. The synthesis of NHC ligands and their corresponding metal complexes are covered in depth. Moreover, the biological activity of NHC-containing complexes, as well as an overview of their theoretical aspects are included. Such metal species are further examined, not only in terms of their catalytic applications, but also of their stereoelectronic parameters and reactivity/stability. Finally, special attention is given to the hot topic of organocatalysis. The book will be of interest to postgraduates, academic researchers and those working in industry.
Spis treści
Chapter 1: Introduction to N-Heterocyclic Carbenes: Synthesis and Stereoelectronic Parameters;
Chapter 2: Computational Studies on the Reactivity of Transition Metal Complexes with N-Heterocyclic Carbene Ligands;
Chapter 3: Synthesis, Activation and Decomposition of N-Heterocyclic Carbene-Containing Complexes;
Chapter 4: Biologically Active N-Heterocyclic Carbene-Metal Complexes;
Chapter 5: Non-Classical N-Heterocyclic Carbene Complexes;
Chapter 6: Early Transition and Rare Earth Metal Complexes with N-Heterocyclic Carbenes;
Chapter 7: NHC-Iron, Ruthenium, AND Osmium Complexes in Catalysis;
Chapter 8: NHC-Cobalt, Rhodium, and Iridium Complexes in Catalysis;
Chapter 9: NHC-Palladium Complexes in Catalysis;
Chapter 10: NHC-Nickel and Platinum Complexes in Catalysis;
Chapter 11: NHC-Copper, Silver AND Gold Complexes in Catalysis;
Chapter 12: Oxidation Reaction with NHC Metal Complexes;
Chapter 13: Reduction Reactions with NHC-Bearing Complexes;
Chapter 14: N-Heterocyclic Carbenes as Organic Catalysts
O autorze
Silvia Díez-González is a Senior Lecturer in the Department of Chemistry at Imperial College London, UK.
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