This truly comprehensive treatise of foldamers, from synthesis to applications in bio-, material-, and nanoscience is at once an introduction to the topic, while providing in-depth accounts on various aspects clearly aimed at the specialist.
The book is clearly structured, with the first part concentrating on structure and foldamer design concepts, while the second part covers functional aspects from properties to applications. The international team of expert authors provides overviews of synthetic approaches as well as analytical techniques.
Spis treści
Foreword
STRUCTURE: FOLDAMER DESIGN CONCEPTS
Foldamers Based on Local Conformation Preferences
Foldamers Based on Remote Intrastrand Interactions
Foldamers Based on Solvophobic Effects
Foldamer Hybrids: Defined Supramolecular Structures from Flexible Molecules
Control of Polypeptide Chain Folding and Assembly
Simulation of Folding Equilibria
FUNCTION: FROM PROPERTIES TO APPLICATIONS
Foldamer-based Molecular Recognition
Biological Application of Foldamers
Protein Design
Nucleic Acid Foldamers: Design, Engineering and Selection of Programmable Biomaterials with Recognition, Catalytic and Self-assembly Properties
Helically Folding Polymers
Polyisocyanides: Stiffened Foldamers
Foldamers at Interfaces
O autorze
Stefan Hecht obtained his doctorate under the guidance of Prof. Jean M. J. Fréchet at the University of California. After becoming a research investigator at Berlin, he is now group leader at the Max-Planck-Institut für Kohlenforschung. He has been a fellow of the Studienstiftung des Deutschen Volkes and has received both the Sofja Kovalevskaja Award of the Alexander von Humboldt Foundation as well as the MIT Technology Review Top 100 Young Innovator Award.
Ivan Huc received his Ph D in 1994 from the Université of Paris VI, jointly supervided by Dr. C. Rolando (Ecole Normale Supérieure) and Prof. J. Rebek Jr. (MIT). After a post-doctoral period with Dr. J.-P. Behr in Illkirch, he received a CNRS researcher position in Nobel Prize winner Prof. J.-M. Lehn’s laboratories in Strasbourg, where he stayed until 1998. Since then, he has been a group leader at the Institut Européen de Chimie et Biologie (Bordeaux) where he holds a research director position.
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