This volume describes important functions and roles of micro RNAs in the vasculature in health, disease, therapeutics and diagnostics. It shows how mi RNAs can be used to improve stem cell-based regenerative therapies of cardiovascular diseases; further the role of mi RNAs as regulators in lipoprotein metabolism in the liver and reverse cholesterol transport is depicted, as well as their pathological function in diabetes and atherosclerosis. The book discusses the use of circulating mi RNAs as disease biomarkers and shows interesting correlations with the amount of detectable mi RNAs in the blood and future cardiovascular risks.
This book is edited and written by leading figures in the field and will be an invaluable resource for academics, researchers and students working on non-coding RNAs in biomedicine, physiology and vascular biology.
Spis treści
1. Non-coding RNAs in the vasculature.- Introduction (Thomas Thum, Stefanie Dimmeler).- Non-coding RNAs in vascular Development and Angiogenesis (Nathan Lawson or Didier Steinier).- 2. Diagnostics of Vascular Diseases using circulating mi RNAs.- 2.1 Basic and Technical Principles (Manuel Mayr).- 2.2 Diagnostics use of circulating mi RNAs in cardiovascular diseases (Andreas Zeiher , Stephan Fichtlscherer).- 2.3 Non-coding RNAs in Ischemic cardiovascular disease and repair mechanisms (incl. AMI, cell therapy) (Ulf Landmesser).- 3. Non-coding RNas in Diabetes and Metabolic Diseases.- 3.1 Non-coding RNAs in vascular complications of Diabetes (Costanza Emanueli).- 3.2 Non-coding RNAs in Metabolic Diseases, Cholesterol Metabolism (Carlos Fernandez-Hernando).- 3.3 Non-coding RNAs in Atherosclerosis and Vascular Inflammation (incl. aging processes and aneurysms, platelelets)(Christian Weber, Feinberg).- 4. Outlook and Perspectives (long non coding RNAs, microvesicles, new therapies, ect) (Thomas Thum, Stefanie Dimmeler).
O autorze
Prof. DDr. Thomas Thum, Institute of Molecular and Translational Therapeutic Strategies Hannover. Medical School Carl-Neuberg Str. 1. 30625 Hannover, Germany Email: [email protected]
Prof. Dr. Stefanie Dimmeler, Institute for Cardiovascular Regeneration Centre of Molecular Medicine, Goethe University Frankfurt. 60590 Frankfurt, Germany Email: [email protected]
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