Over the last three decades a lot of research on the role of
metals in biochemistry and medicine has been done. As a result many
structures of biomolecules with metals have been characterized and
medicinal chemistry studied the effects of metal containing
drugs.
This new book (from the EIBC Book Series) covers recent advances
made by top researchers in the field of metals in cells [the
'metallome’] and include: regulated metal ion
uptake and trafficking, sensing of metals within cells and across
tissues, and identification of the vast cellular factors designed
to orchestrate assembly of metal cofactor sites while minimizing
toxic side reactions of metals. In addition, it features
aspects of metals in disease, including the role of metals in
neuro-degeneration, liver disease, and inflammation, as a way to
highlight the detrimental effects of mishandling of metal
trafficking and response to 'foreign’ metals. With the breadth of
our recently acquired understanding of metals in cells, a book that
features key aspects of cellular handling of inorganic elements is
both timely and important. At this point in our understanding, it
is worthwhile to step back and take an expansive view of how far
our understanding has come, while also highlighting how much we
still do not know.
The content from this book will publish online, as part of
EIBC in December 2013, find out more about the
Encyclopedia of Inorganic and Bioinorganic Chemistry, the
essential online resource for researchers and students working in
all areas of href=’http://onlinelibrary.wiley.com/book/10.1002/9781119951438’>inorganic
and bioinorganic chemistry.
O autorze
Prof. Robert A. Scott (Editor-in-Chief Encyclopedia of Inorganic and Bioinorganic Chemistry)
Distinguished Research Professor, University of Georgia, USA.
Prof. Valeria Culotta, Biochemistry and Molecular Biology Department, Joint Departmental Affiliations Environmental Health Sciences
Research in the Culotta lab focuses on the role of metal ions and oxygen radicals in biology and disease. Metal ions such as copper, iron and manganese are not only trace nutrients but can be quite toxic. One mechanism of toxicity is through generation of reactive oxygen species (ROS) that have been implicated in numerous human disorders from neurodegeneration to cancer to aging. Through molecular genetic approaches and high through-put genetic screens in yeast, we have identified a number genes and pathways that are involved in transition metal and reactive oxygen metabolism. Virtually all are well conserved throughout eukaryotes including humans. Our laboratory uses a combination of yeast, C. elegans and cell culture systems at the crossroads of bioinorganic chemistry, cell biology and molecular genetics.
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