This four-volume set (CCIS 643, 644, 645, 646) constitutes the refereed proceedings of the 16th Asia Simulation Conference and the First Autumn Simulation Multi-Conference, Asia Sim / SCS Autumn Sim 2016, held in Beijing, China, in October 2016. The 265 revised full papers presented were carefully reviewed and selected from 651 submissions. The papers in this third volume of the set are organized in topical sections on Cloud technologies in simulation applications; fractional calculus with applications and simulations; modeling and simulation for energy, environment and climate; SBA virtual prototyping engineering technology; simulation and Big Data.