Demonstrating the interdisciplinary nature of modern glycosciences, this volume covers research in the fields of polysaccharides and small carbohydrates from the synthetic and structural viewpoints, with applications ranging from biology to the bioeconomy. Key aspects of the synthesis and properties of imino disaccharides and regioselective glycosylation reactions are reviewed, glycosyltransferase inhibitors are shown to be potential future therapeutic agents, protein-carbohydrate interactions in plant cell-wall biodegradation are targeted by the use of glycan microarrays, biological properties of polysaccharidic microbial surface antigens are discussed with respect to their intimate structure, and contributions on carbohydrate-based hydrogelators, green/blue sugar-based surfactants and carbohydrate-based green solvents illustrate the modern design of tomorrow’s chemicals. With the increase in volume, velocity and variety of information, researchers can find it difficult to keep up to date with the literature in their field and this book remains a valuable addition to any researcher’s library.
Tabela de Conteúdo
Synthesis and Biological Properties of Imino-disaccharides and -oligosaccharides; Bacterial Polysaccharides as Major Surface Antigens: Interest in O-acetyl Substitutions; Regioselective glycosylation: What’s new?; Glycosyltransferase Inhibitors: A Promising Strategy to Pave a Path from Laboratory to Therapy; Targeting Protein-Carbohydrate Interactions in Plant Cell Wall Biodegradation: the power of carbohydrate microarrays; Low Melting Carbohydrate Mixtures and Aqueous Carbohydrates – an effective green medium for organic synthesis; Surfactants Based on Green/Blue Sugars: towards new functionalities in formulations; Low Molecular Weight Carbohydrate-based Hydrogelators
Sobre o autor
Dr Yves Queneau, Research Director at CNRS, is Head of the Organic and Bioorganic Chemistry Laboratory at INSA Lyon, Deputy-Director of the “Institut de Chimie et Biochimie Moléculaires et Supramoléculaires” (ICBMS), University of Lyon, France and Honorary Professor at the University of Hull, UK. After his doctorate on aqueous Diels-Alder reactions involving glycodienes under the supervision of Professor André Lubineau (Orsay, 1988) he was appointed as CNRS fellow and worked on cycloaddition reactions towards complex sugars. He then spent one year in 1992 in Professor Samuel J. Danishefsky’s group in Memorial Sloan Kettering Cancer Center in New York, USA. He later moved to Lyon in a mixed CNRS-industrial research facility dedicated to sucrose chemistry (1995-2003) before joining its present position where he develops his research in organic and biological chemistry with a particular interest for the use of carbohydrates as renewable raw materials.
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