Christian Rommel & Bart Vanhaesebroeck 
Phosphoinositide 3-kinase in Health and Disease [PDF ebook] 
Volume 2

PI3K has become a very intense area of research, with over 2000 publications on PI3K in Pub Med for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target