From DNA and RNA to proteins and vitamins the role of nitrogen is central in organismal metabolism. The Chemical Biology of Nitrogen comprehensively examines how the chemistry available to both inorganic and organic nitrogen compounds both enable and conditions the vast array of nitrogen biologies. This book provides a chemocentric approach to both the inorganic and organic chemical biology of nitrogen. Following an introduction to nitrogen trivalency the book progresses through the logic of inorganic nitrogen metabolism and organic nitrogen metabolites to nitrogen proteomics with an integrative approach to understanding the role of nitrogen in its many biologic roles. Authored by a renowned scientist and educator, this book is ideal for researchers in chemical biology and nitrogen metabolism and will be of particular interest to advanced students and postgraduates in biochemistry and chemical biology.
Tabela de Conteúdo
Introduction to Nitrogen Chemical Biology;
Inorganic Nitrogen Biochemistry and Dinitrogen Reduction to Ammonia by Nitrogenase;
Ammonia Oxidation: Nitrification vs. Anammox;
Nitrate Ion Reductive Metabolism: Bifurcation Between Five-electron or Eight-electron Reductions;
Chemical Strategies Underlying the Biological Flux of Inorganic Nitrogen Species;
Amination Reactions: Incorporation of Ammonia Into Amino Acid Frameworks;
When Ammonia Becomes Toxic: Ureido and Guanidinium Forms of Organic Nitrogen;
Metabolic Capture of Amines, Imines and Enamines;
Nitrogen Heterocycles;
B Vitamin Nitrogen Heterocycles;
Tetrapyrrole Macrocycles: Aminopyrroles and the Pigments of Life;
Organic Nitrogen Oxygenations;
Nitriles, Cyanohydrins and Cyanogenesis;
One-electron Nitrogen Chemical Biology;
Peptide Bond Formation Strategies in Nonribosomal and Ribosomal Assembly Lines;
Nitrogen Side Chains in Enzyme Catalysis and Posttranslational Modifications
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