Many newly proposed drugs suffer from poor water solubility,
thus presenting major hurdles in the design of suitable
formulations for administration to patients. Consequently, the
development of
techniques and materials to overcome these hurdles is a major area
of research in pharmaceutical companies.
Drug Delivery Strategies for Poorly Water-Soluble Drugs provides
a comprehensive overview of currently used formulation strategies
for hydrophobic drugs, including liposome formulation, cyclodextrin
drug carriers, solid lipid nanoparticles, polymeric drug
encapsulation delivery systems, self-microemulsifying drug
delivery systems, nanocrystals, hydrosol colloidal dispersions,
microemulsions, solid dispersions, cosolvent use, dendrimers,
polymer- drug conjugates, polymeric micelles, and mesoporous silica
nanoparticles. For each approach the book discusses the main
instrumentation, operation principles and theoretical background,
with a focus on critical
formulation features and clinical studies. Finally, the book
includes some recent and novel applications, scale-up
considerations and regulatory issues.
Drug Delivery Strategies for Poorly Water-Soluble Drugs is an
essential multidisciplinary guide to this important area of drug
formulation for researchers in industry and academia working in
drug
delivery, polymers and biomaterials.
Sobre o autor
Dennis Douroumis
University of Greenwich, UK
Alfred Fahr
Friedrich-Schiller University of Jena, Germany
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