This book constitutes the refereed proceedings of the 29th International Conference on Advanced Information Systems Engineering, CAi SE 2017, held in Essen, Germany, in June 2017. The 37 papers presented together with 3 keynote papers in this volume were carefully reviewed and selected from 175 submissions. The papers are organized in topical sections on information systems architecture; business process alignment; user knowledge discovery; business process performance; big data exploration; process variability management; information systems transformation and evolution; business process modeling readability; business process adaption; data mining; process discovery; business process modeling notation.