Gerhard Gross & Thomas Häupl 
Stem Cell-Dependent Therapies [PDF ebook] 
Mesenchymal Stem Cells in Chronic Inflammatory Disorders

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Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (Gv HD).
This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are Gv HD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation.

€250.00
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Sobre o autor

Gerhard Gross, Helmholtz Centre for Infection Research, Braunschweig, Germany; Thomas Häupl, Charité, Berlin, Germany.

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Língua Inglês ● Formato PDF ● Páginas 426 ● ISBN 9783110298307 ● Tamanho do arquivo 3.9 MB ● Editor Gerhard Gross & Thomas Häupl ● Editora De Gruyter ● Cidade Berlin/Boston ● Publicado 2013 ● Edição 1 ● Carregável 24 meses ● Moeda EUR ● ID 6360206 ● Proteção contra cópia Adobe DRM
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