This book features contributions from experts in cell biology,
genetics, neurobiology, immunology and structural biology.
The unifying element is that they all study processes of cell shape
change and motility. Several key questions in this field of
research are discussed:
* What are the organising principles behind cell shape
change?
* Are there ‘master switches’ present in every cell
type?
* How are extracellular signals interpreted by the cell in order
to activate intracellular mechanisms?
* What is the influence of the extracellular matrix on cell
movement and internal signalling pathways?
* How do pathogens subvert cellular systems in order to stimulate
or block their uptake?
The book addresses all of these important questions. Data
are presented on the key proteins that regulate cell shape: the GTP
binding proteins of the Rho family. There are also extensive
discussions of the potential applications of the data to clinical
problems, particularly that of cell motility in cancer.
Tabela de Conteúdo
Novartis Foundation symposium on Signalling networks in cell
shape and motility held in collaboration with the Institute of Cell
and Molecular Biology, Singapore, in Singapore on August 30th-1st
September 2004.
Editors:Gregory Bock (Organizer) and Jamie Goode.
This symposium is based on a proposal made by Uttam
Surana.
Gary Borisy Chair’s introduction.
Tadaomi Takenawa – From N-WASP to WAVE: key molecules for
regulation of cortical actin organization.
Discussion.
Margaret A. Titus – A conserved role for myosin VII in
adhesion.
Discussion.
General discussion I.
David G. Drubin, Marko Kaksonen, Christopher Toret and Yidi Sun
– Cytoskeletal networks and pathways involved in endocytosis.
Discussion.
Michele Knaus, Philippe Wiget, Yukiko Shimada and Matthias Peter
– Control of cell polarity in response to intra- and extracellular
signals in budding yeast.
Discussion.
Fred Chang, Becket Feierbach and Sophie Martin – Regulation of
actin assembly by microtubules in fission yeast cell polarity.
Discussion.
Atsuo T. Sasaki and Richard A. Firtel – Finding the way:
directional sensing and cell polarization through Ras
signaling.
Discussion.
Takashi Watanabe, Ju Noritake and Kozo Kaibuchi – Roles of
IQGAP1 in cell polarization and migration.
Discussion.
Gregg G. Gundersen, Ying Wen, Christina H. Eng, Jan Schmoranzer,
Noemi Cabrera-Poch, Edward J. S.Morris, Michael Chen and Edgar R.
Gomes – Regulation of microtubules by Rho GTPases in migrating
cells.
Discussion.
Eyal D. Schejter – Actin organization in the early Drosophila
embryo.
Discussion.
Yasuyuki Fujita and Vania Braga – Epithelial cell shape and Rho
small GTPases.
Discussion.
W. James Nelson, Frauke Drees and Soichiro – Yamada Interaction
of cadherin with the actin cytoskeleton.
Discussion.
Martin J.Humphries, Zohreh Mostafavi-Pour, Mark R.Morgan,
Nicholas O. Deakin, Anthea J. Messent and Mark D. Bass –
Integrin-syndecan co-operation governs the assembly of signalling
complexes during cell spreading.
Discussion.
Keith Mostov, Paul Brakeman, Anirban Datta, Ama Gassama, Leonid
Katz, Minji Kim, Pascale Leroy, Max Levin, Kathleen Liu, Fernando
Martin, Lucy E. O’Brien, Marcel Verges, Tao Su, Kitty Tang,
Naoki Tanimizu, Toshiyuki Yamaji and Wei Yu – Formation of
multicellular epithelial structures.
Discussion.
Kathryn M. Eisenmann, Jun Peng, Bradley J.Wallar and Arthur S.
Alberts – Rho GTPase: formin pairs in cytoskeletal remodeling.
Discussion.
Final discussion.
Index of contributors.
Subject index.
Sobre o autor
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.
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