At the end of 2019, the world came across a virus, SARS-Co V-2, which causes a disease classified as COVID-19. The virus is highly transmissible and causes an acute respiratory syndrome that ranges from mild symptoms in about 80% cases to very severe symptoms with respiratory failure in 5% to 10% of cases. The epicenter of the outbreak of this pandemic was Wuhan, a city in China’s Hubei Province. The World Health Organization has declared the outbreak of COVID-19 to be a pandemic and classified it as a high global risk. Human health risk assessment for COVID-19 depends on the characteristics of the virus and includes the process of gathering and analyzing environmental and health information using specific techniques to support decision making, systematically taking actions, and articulating the collected information within and between sectors for promoting health and improving the social and living conditions of populations. To assess COVID-19 risk factors, it is important to consider and document all relevant information available at the time of assessment. In this way, decision making will get a direction and the assessment process will get recorded, which includes evaluation of the risk factors, control measures, methods used for evaluation, why they were considered important, and their order of priority. This book addresses in detail the challenges posed by the virus and presents up-to-date knowledge on safety risk assessment and economics, as well as ethical, legal, and social implications (ELSI) of COVID-19.