This book constitutes the proceedings of the 17th International Conference on Research Challenges in Information Sciences, RCIS 2023, which took place in Corfu, Greece, during May 23-26, 2023. It focused on the special theme "Information Science and the Connected World".The scope of RCIS is summarized by the thematic areas of information systems and their engineering; user-oriented approaches; data and information management; business process management; domain-specific information systems engineering; data science; information infrastructures, and reflective research and practice.The 28 full papers presented in this volume were carefully reviewed and selected from a total of 87 submissions. The book also includes 15 Forum papers and 6 Doctoral Consortium papers. The contributions were organized in topical sections named: Requirements; conceptual modeling and ontologies; machine learning and analytics; conceptual modeling and semantic networks; business process design and computing in the continuum; requirements and evaluation; monitoring and recommending; business process analysis and improvement; user interface and experience; forum papers; doctoral consortium papers. Two-page abstracts of the tutorials can be found in the back matter of the volume.