Cytotoxic drugs (sometimes known as antineoplastics) describe a group of medicines that containchemicals which are toxic to cells, preventing their replication or growth, and so are used to treat cancer.They can also be used to treat a number of other disorders such as rheumatoid arthritis and multiplesclerosis. Once inside the body, their action is not generally tightly targeted, and they can produce sideeffects both to the patients and others who become exposed. This book describes cutting-edgemethods for examining the mechanisms of cellular resistance to anticancer cytotoxics in humantumors. There are detailed instructions and extensive troubleshooting tips that allow researcherseffectively to study a wide variety of drug resistance mechanisms. Each method is designed to helpidentify the correlation between molecular and biochemical data and the clinical responses of thepatient. The methods presented in this book are powerful tools for investigating all the clinicallyrelevant mechanisms used as markers of the biological response to anticancer chemotherapeuticstoday. This book will give immense pleasure to the reader and is a good companion to the students andresearch scholars alike.
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