Cough is the most familiar symptom of respiratory disease, and a
problem which general practitioners must deal with on a daily
basis. This timely volume draws together a wealth of recent
research into the mechanisms, pharmacology and therapies for cough,
and places these in clinical context. The text incorporates
guidelines on the most common causes of cough, discusses treatments
and pitfalls in management, summarizes current research on
physiology, pharmacology and treatment of cough, and gives
practical advice on diagnosis and management issues for the
clinician.
Cough: Causes, Mechanisms and Therapy is the most
comprehensive, up-to-date account of the subject. It will update
clinical and basic medical scientists, and promote future research.
Readers are encouraged to implement the clinical implications of
the discussion into routine practice. This volume will appeal to
all those involved in the treatment of respiratory disease,
particularly those in hospital respiratory units, and will also be
of use to interested general practitioners.
Tabela de Conteúdo
Contributors.
Preface.
Section 1: Introduction.
1 The clinical and pathophysiological challenge of cough.
2 Epidemiology of cough.
3 A brief overview of the mechanisms of cough.
Section 2: Cough in the clinic.
4 Clinical assessment of cough.
5 Measurement and assessment of cough.
6 Cough sensitivity: the use of provocation tests.
7 Causes, assessment and measurement of cough in children.
8 The quality of life in coughers Section 3: Clinical
conditions with cough.
9 Cough in lower airway infections.
10 Cough in gastro-oesophageal reflux.
11 Cough in postnasal drip, rhinitis and rhinosinusitis.
12 Cough and airway hyperresponsiveness.
13 Cough in chronic obstructive pulmonary disease (COPD).
14 Cough in suppurative airway diseases.
15 Cough in cancer patients.
.
Section 4: Pathophysiology.
16 Sensory pathways for the cough reflex.
17 Neurogenesis of cough.
18 Plasticity of vagal afferent fibres mediating cough.
19 Motor mechanisms and the mechanics of cough.
20 Mucus hypersecretion and mucus clearance in cough.
21 Animal models of cough.
Section 5: Therapy.
22 Mechanisms of actions of centrally acting antitussives –
electrophysiological and neurochemical analysis.
23 Pharmacology of peripherally acting antitussives.
24 Current and potential future antitussive therapies.
25 Placebo effects of antitussive treatments on cough associated
with acute upper respiratory tract infection.
26 Mucoactive agents for the treatment of cough.
27 Management of cough.
Index
Sobre o autor
Fan Chung is Professor of Respiratory Medicine and Head of Experimental Studies Medicine at National Heart & Lung Institute, Imperial College London, and is Consultant Physician at the Royal Brompton & Harefield NHS Trust, London.
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