Lihe Zhang & Zhen Xi 
Medicinal Chemistry of Nucleic Acids [PDF ebook] 

FOREWORD vii
CONTRIBUTORS xi
INTRODUCTION xv
1 RECENT ADVANCES IN CARBOCYCLIC NUCLEOSIDES: SYNTHESIS AND
BIOLOGICAL ACTIVITY 1
Jianing Wang, Ravindra K. Rawal, and Chung K. Chu
2 STRUCTURES AND FUNCTIONS OF NUCLEIC ACIDS MODIFIED WITH S, Se,
AND Te AND COMPLEXED WITH SMALL MOLECULES 101
Wen Zhang, Jia Sheng, and Zhen Huang
3 UNRAVELING OF THE NAD CYCLIZING AND CALCIUM SIGNALING
FUNCTIONS OF HUMAN CD38 142
Hon Cheung Lee
4 DNA AND RNA BINDING SMALL MOLECULES 164
Shibo Li and Zhen Xi
5 G-QUADRUPLEX DNA AND ITS LIGANDS IN ANTICANCER THERAPY
206
Zhi-Shu Huang, Jia-Heng Tan, Tian-Miao Ou, Ding Li, and
Lian-Quan Gu
6 MOLECULAR MODELING IN NUCLEIC ACID-TARGETED DRUG DESIGN
258
Lidan Sun, Hongwei Jin, Liangren Zhang, and Lihe Zhang
7 STRUCTURE OF 10-23 DNAzyme IN COMPLEX WITH THE TARGET
RNA IN SILICO–A PROGRESS REPORT ON THE MECHANISM OF
RNA CLEAVAGE BY DNA ENZYME 272
Oleksandr Plashkevych and Jyoti Chattopadhyaya
8 LABELING OLIGONUCLEOTIDES TOWARD THE BIOMEDICAL PROBE
292
Il Joon Lee and Byeang Hyean Kim
9 LOCKED NUCLEIC ACID OLIGONUCLEOTIDES TOWARD CLINICAL
APPLICATIONS 335
Rakesh N. Veedu and Jesper Wengel
10 THE PHARMACOKINETICS RESEARCH OF NUCLEIC ACID DRUGS 349
Shengqi Wang, Dandan Lu, Qingqing Wang, Haifeng Song, Chan Gao,
Caihong Liu, and Ying Wang
11 INDUCIBLE RNAi AND DRUG TARGET VALIDATION 390
Wei Xiong, Jing Zhao, Yufan Zhang, Jinxi Wang, Yong-Xiang Zheng,
Qiu-Chen He, Li-He Zhang, and De-Min Zhou
12 si RNA: THE SPECIFICITY AND OFF-TARGET EFFECTS 405
Quan Du, Huang Huang, and Zicai Liang
INDEX 423

LI-HE ZHANG is President of the academic committee of State
Key Laboratory of Natural and Biomimetic Drugs, as well as
Professor of Medicinal Chemistry at Peking University. He is also a
member of the Chinese Academy of Sciences, Fellow of the Royal
Society of Chemistry, former vice president of the Chinese
Pharmaceutical Association, and past president of the Asian
Federation of Medicinal Chemistry.
ZHEN XI, Ph D, is Deputy Director of the State Key
Laboratory of Elemento-organic Chemistry, as well as Professor of
Pesticide Science and Chemical Biology, and Vice Dean of the
College of Chemistry at Nankai University. He holds seven patents
and has written a number of reviews and book chapters and
sixty-four original research articles.
JYOTI CHATTOPADHYAYA, Ph D, DSc, is the University Chair
of Bioorganic Chemistry and the chair of the Chemical Biology
Program at Uppsala University. He is a guest professor of chemistry
at both Jilin University and Nankai University. He has written over
410 peer-reviewed original research articles and is also on the
editorial boards of several international journals.