In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals.
Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others.
Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.
Tabela de Conteúdo
Introduction
Yehuda Shoenfeld
SECTION A: Mosaic of Autimmunity
1. Adjuvants’ Role in Infection and Autoimmunity
Eitan Israeli, Miri Blank and Yehuda Shoenfeld
2. Infections as Adjuvants for Autoimmunity: The Adjuvant Effect
Quan M. Nhu and Noel R. Rose
3. Experimental Models of Adjuvants
Nicola Bassi, Mariele Gatto, Anna Ghirardello and Andrea Doria
4. Answers to Common Misconceptions Regarding the Toxicity of Aluminum Adjuvants in Vaccines
Lucija Tomljenovic and Christopher A. Shaw
5. Allergy and Autoimmunity Caused by Metals: A Unifying Concept
Vera Stejskal
6. Genetics and Vaccinology
John Castiblanco and Juan-Manuel Anaya
7. Silicone and Autoimmune (Autoinflammatory) Syndrome Induced by Adjuvants (ASIA)
Yair Levy and Rotem Baytner-Zamir
8. Silicone Breast Implants and Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants: A Literature Search
Elisabetta Borella, Eitan Israeli and Yehuda Shoenfeld
9. Autoantibodies Induced by Vaccine
Natasa Toplak and Tadej Avcin
10. The ASIA Syndrome Registry
Ignasi Rodriguez-Pintó and Yehuda Shoenfeld
11. Vaccination and Autoimmune Diseases
Carla Gonçalves, Schahin Saad, Clóvis A. Silva and Eloisa Bonfá
12. Vaccination in Patients with Autoimmune Inflammatory Rheumatic Diseases
Abdulla Watad, Alessandra Soriano and Yehuda Shoenfeld
SECTION B: Studies on Autoimmune Conditions Induced by Vaccination
13. Measles, Mumps and Rubella Vaccine: A Triad to Autoimmunity
Carlo Perricone, Guido Valesini and Yehuda Shoenfeld
14. Yellow Fever Vaccine and Autoimmunity
Roger A. Levy and Rodrigo Poubel V. Rezende
15. Antiphospholipid Syndrome and Vaccines
Miri Blank and Paola Cruz-Tapias
16. Hepatitis B Vaccination and Autoimmunity
Daniel S. Smyk, Lazaros I. Sakkas, Yehuda Shoenfeld and Dimitrios P. Bodganos
17. Adverse Reactions to Human Papillomavirus (HPV) Vaccines
Lucija Tomljenovic and Christopher A. Shaw
18. Influenza Vaccine and Autoimmune Diseases
Luis J. Jara, Gabriela Medina, Pilar Cruz Dominguez, Olga Vera-Lastra, Miguel A. Saavedra, Mónica Vázquez del Mercado and Minoru Satoh
19. Vaccines and Autoimmunity: Meningococcal Vaccines
Giovanna Passaro, Alessandra Soriano and Raffaele Manna
20. Pneumococcal Vaccines and Autoimmune Phenomena
Elisabetta Borella, Nancy Agmon-Levin, Andrea Doria and Yehuda Shoenfeld
21. BCG and Autoimmunity
Luigi Bernini, Carlo Umberto Manzini, Clodoveo Ferri
SECTION C: Autoimmune Diseases Solicited by Vaccination
22. Systemic Lupus Erythematosus (SLE) Induced by Vaccines
Nurit Katz-Agranov and Gisele Zandman-Goddard
23. Vasculitides
Alessandro Soriano, Rotem Inbar, Giovanna Passaro and Raffele Manna
24. Vaccinations in Rheumatoid Arthritis
Eitan Giat and Merav Lidar
25. Undifferentiated Connective Tissue Diseases (UCTDs)
Maria Martinelli, Carlo Perricone and Yehuda Shoenfeld
26. Vaccines, Infections and Alopecia Areata
Yaron Zafrir, Sharon Baum, Nancy Agmon-Levin and Yehuda Shoenfeld
27. Aluminium Particle Biopersistence, Systemic Transport and Long-Term Safety: Macrophagic Myofasciitis and Beyond
Romain K Gherardi, Josette Cadusseau and François-Jérôme Authier
28. Immune Thrombocytopenic Purpura: Between Infections and Vaccinations
Carlo Perricone, Maurizio Rinaldi, Roberto Perricone and Yehuda Shoenfeld
29. Vaccinations and Type 1 Diabetes
Alessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ele Ferrannini and Poupak Fallahi
30. Narcolepsy and H1N1 the Vaccine
María-Teresa Arango, Shaye Kivity, Nancy Agmon-Levin, Gili Givaty, Joab Chapman, Yehuda Shoenfeld
31. Non-nutritional Environmental Factors Associated with Celiac Disease: Infections and Vaccinations
Aaron Lerner
32. Polymyalgia Rheumatica
Alessandra Soriano and Raffaele Manna
33. Acute Disseminated Encephalomyelitis (ADEM): Idiopathic, Post-infectious and Post Vaccination
Dimitrios Karussis and Panayiota Petrou
34. Fibromyalgia, Chronic Fatigue, Functional Disorders and Vaccination: Where Do We Stand?
Jacob N. Ablin and Dan Buskila
35. Bullous Dermatoses, Infectious Agents and Vaccines
Yaron Zafrir, Nancy Agmon-Levin and Sharon Baum
36. Infections, Vaccinations and the Chronic Fatigue Syndrome
Hussein Mahagna, Naim Mahroum and Howard Amital
37. Myositis and Vaccines
Ignasi Rodriguez-Pintó and Yehuda Shoenfeld
Sobre o autor
Yehuda Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair of Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University in Tel Aviv, Israel. He is also Founder of the Center for Autoimmune Diseases, both at the Sheba Medical Center in Tel Hashomer, Israel.
Nancy Agmon-Levin is a specialist in Clinical Immunology and Allergology, and serves as Deputy Head of the Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center in Tel Hashomer, Israel. She is also President of the Israel Association for Allergy and Clinical Immunology (IAACI).
Lucija Tomljenovic is a Senior Postdoctoral Fellow in the Neural Dynamics Research Group at the University of British Columbia in Vancouver, BC, Canada.
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