Until recently, a modest knowledge of genetics was more than
adequate for the daily practice of clinical cardiology, but
advances in genetics and genomics are changing cardiovascular
medicine in fundamental ways. The identification of the genetic
basis of several forms of dyslipidemia, hypertension, diabetes,
cardiomyopathies, and vascular diseases signalled the new
importance of genetics in clinical medicine.
In this timely volume, Drs. Dzau and Liew – both pioneers
in the area – help cardiologists understand:
* how cardiovascular genetics may remodel the way
cardiovascular medicine is practiced
* what material has immediate relevance to the practicing
clinician
* how to incorporate genetics and genomics in your practice
to ensure up-to-date patient care
The book opens with introductory chapters, then discusses:
* cardiovascular single gene disorders
* cardiovascular polygenic disorders
* therapies and applications
Outstanding contributors write on their areas of expertise,
making Cardiovascular Genetics and Genomics for the
Cardiologist both authoritative and comprehensive. If you want
to gain a better appreciation of how genetics and genomics are
already shaping current practice and may potentially revolutionize
cardiology, look no further than this dependable reference.
Tabela de Conteúdo
Contributors.
Foreword.
Introduction.
1 The gene in the twenty-first century.
Choong-Chin Liew, Victor J. Dzau.
Part I: Cardiovascular single gene disorders.
2 Monogenic hypercholesterolemia.
Ruth Mc Pherson.
3 Hypertrophic cardiomyopathy.
Ali J. Marian.
4 Dilated cardiomyopathy and other cardiomyopathies.
Mitra Esfandiarei, Robert Yanagawa, Bruce M. Mc Manus.
5 The long QT syndrome.
Sabina Kupershmidt, Kamilla Kelemen, Tadashi
Nakajima.
Part II: Cardiovascular polygenic disorders.
6 Atherosclerosis.
Päivi Pajukanta, Kiat Tsong Tan, Choong-Chin
Liew.
7 Heart failure.
Markus Meyer, Peter Van Buren.
8 The implications of genes on the pathogenesis, diagnosis and
therapeutics of hypertension.
Kiat Tsong Tan, Choong-Chin Liew.
Part III: Therapies and applications.
9 Gene therapy for cardiovascular disease: inserting new genes,
regulating the expression of native genes, and correcting genetic
defects.
Ion S. Jovin, Frank J. Giordano.
10 Stem cell therapy for cardiovascular disease.
Emerson C. Perin, Guilherme V. Silva.
11 Pharmacogenetics and personalized medicine.
Julie A. Johnson, Issam Zineh.
12 The potential of blood-based gene profiling for disease
assessment.
Steve Mohr, Choong-Chin Liew.
Index.
Colour plates
Sobre o autor
Victor J. Dzau, MD
James B. Duke Professor of Medicine, Director, Mandel Center
for Hypertension and Atherosclerosis Research; and
Chancellor for Health Affairs, Duke University, Durham,
USA
Choong-Chin Liew, Ph D
Professor Emeritus, Department of Laboratory Medicine and
Pathobiology, University of Toronto, Toronto, Ontario, Canada;
and (formerly) Visiting Professor of Medicine, Brigham and
Women’s Hospital, Harvard Medical School, Boston, MA, USA
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