Strategies for providing optimal care to this high-risk patient group
The immunocompromised patient population is increasing throughout the world. Major advances in transplantation techniques have expanded access to lifesaving therapies and improved outcomes in these high-risk populations. An understanding of the biology of these infections, host conditions, and the limitations of technologies used to detect and quantify such pathogens is critical to optimal care.
This new edition of Diagnostic Microbiology of the Immunocompromised Host covers all aspects of state-of-the-art diagnostics for infectious complications in the immunocompromised patient. Editors Randall Hayden, Karen Carroll, Yi-Wei Tang and Donna Wolk, assembled the contributions of a team of preeminent authors to discuss a broad range of topics, including
- relevant aspects of host biology, antineoplastic, and transplantation techniques and the basis of immunosuppressive conditions ranging from diabetes to age-related immunosuppression
- approaches, interpretations, and limitations of laboratory diagnosis of infections by a wide range of specific etiologic agents
- laboratory diagnosis of infections of specific organ systems, such as respiratory tract infections, gastrointestinal tract infections, and central nervous system infections
- special topics such as prosthetic devices and catheters, healthcare acquired infections, and morphologic considerations (anatomic pathology)
- future diagnostic technologies and their potential impact on the field
Diagnostic Microbiology of the Immunocompromised Host is a resource for laboratory medicine specialists, pathologists, technologists, students, and clinical care professionals who are involved or interested in the care of the immunocompromised host.
If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.
Table of Content
Contributors ix
Foreword xvii
Preface xix
I. OVERVIEW OF INFECTIONS IN THE IMMUNOCOMPROMISED HOST
1. Overview of Infections in the Immunocompromised Host 3
Lesia K. Dropulic and Howard M. Lederman
II. LABORATORY DIAGNOSIS: APPROACHES, INTERPRETATIONS, AND LIMITATIONS INFECTIONS BY SPECIFIC ETIOLOGIC AGENTS
2. Human Immunodeficiency Virus 53
Wendy S. Armstrong, Jeannette Guarner, Colleen S. Kraft, and Angela M. Caliendo
3. Chronic Hepatitis B, C, and D 69
Bryan R. Cobb and Alexandra Valsamakis
4. Cytomegalovirus 97
M. Veronica Dioverti and Raymund R. Razonable
5. Epstein-Barr Virus 127
Andrew Nowalk and Michael Green
6. Herpes Simplex Virus and Varicella-Zoster Virus 135
Myron J. Levin, Adriana Weinberg, and D. Scott Schmid
7. Human Herpesviruses 6A, 6B and 7 157
Henri Agut, Pascale Bonnafous, and Agnès Gautheret-Dejean
8. Human Papillomavirus 177
Eileen M. Burd and Christina L. Dean
9. Polyomaviruses 197
Linda Cook
10. Adenovirus 217
Michael G. Ison and Randall T. Hayden
11. Respiratory RNA Viruses 233
Richard L. Hodinka
12. Enteroviruses and Parechoviruses 273
James J. Dunn
13. Parvovirus B19 297
Marie Louise Landry
14. Filamentous Fungi 311
Margaret V. Powers-Fletcher, Brian A. Kendall, Allen T. Griffin, and Kimberly E. Hanson
15. Yeasts 343
Sean X. Zhang and Nathan P. Wiederhold
16. Mycobacteria 367
Patricia J. Simner, Gail L. Woods, and Nancy L. Wengenack
17. Aerobic Actinomycetes of Clinical Significance 391
A. Brian Mochon, Den Sussland, and Michael A. Saubolle
18. Parasites 411
Elitza S. Theel and Bobbi S. Pritt
19. Selected Topics in Aerobic Bacteriology 467
Geraldine Hall and Karen C. Carroll
20. Selected Topics in Anaerobic Bacteriology 493
Deirdre L. Church
III. LABORATORY DIAGNOSIS: APPROACHES, INTERPRETATIONS, AND LIMITATIONS INFECTIONS OF SPECIFIC ORGAN SYSTEMS
21. Lower Respiratory Tract Infections 539
Karen C. Carroll and La’Tonzia L. Adams
22. Genitourinary Tract Infections 569
Odaliz Abreu Lanfranco and George J. Alangaden
23. Gastrointestinal Infections 613
Kevin Alby and Irving Nachamkin
24. Central Nervous System Infections 629
Andrea J. Zimmer, Victoria E. Burke, and Karen C. Bloch
25. Bloodstream Infections 653
Raquel M. Martinez and Donna M. Wolk
26. Skin and Soft Tissue Infections 691
Anne Spichler Moffarah, Mayar Al Mohajer, Bonnie L. Hurwitz, and David G. Armstrong
IV. SPECIAL TOPICS
27. Prosthetic Device Infections 711
Raquel M. Martinez, Thomas R. Bowen, and Michael A. Foltzer
28. Hospital-Associated Infections 735
N. Esther Babady
29. Surgical Pathologic Diagnosis 759
Mary K. Klassen-Fischer and Ronald C. Neafie
Index 781
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